Baicalein Inhibits Progression of Gallbladder Cancer Cells by Downregulating ZFX
Baicalein Inhibits Progression of Gallbladder Cancer Cells by Downregulating ZFX
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黄芩素通过下调 ZFX 抑制胆囊癌细胞的进展
DOI：
10.1371/journal.pone.0114851
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发表时间：
2015-01-24
期刊：
影响因子：
3.7
通讯作者：
Liu, Ying-Bin
中科院分区：
文献类型：
--
作者：
Liu, Tian-Yu;Gong, Wei;Liu, Ying-Bin
黄芩素是一种应用广泛的中草药，具有多种药理活性。然而，黄芩素对胆囊癌（GBC）抗增殖和抗转移作用的确切机制仍知之甚少。因此，本研究的目的是评估黄芩素对GBC的抗增殖和抗转移作用及其相关机制。在本研究中，我们发现，黄芩素处理诱导了显着的增殖抑制作用的GBC-SD和SGC 996细胞，两个广泛使用的胆囊癌细胞系，并促进凋亡。此外，黄芩素处理抑制GBC细胞的转移。此外，我们首次证明黄芩素通过下调锌指蛋白X-连接（ZFX）的表达水平来抑制GBC细胞的生长和转移。总之，我们的研究表明，黄芩素可能是一个潜在的植物化学黄酮类化合物的治疗GBC和ZFX可能作为一个分子标记物或预测GBC的目标。
Baicalein, a widely used Chinese herbal medicine, has multiple pharmacological activities. However, the precise mechanisms of the anti-proliferation and anti-metastatic effects of baicalein on gallbladder cancer (GBC) remain poorly understood. Therefore, the aim of this study was to assess the anti-proliferation and anti-metastatic effects of baicalein and the related mechanism(s) on GBC. In the present study, we found that treatment with baicalein induced a significant inhibitory effect on proliferation and promoted apoptosis in GBC-SD and SGC996 cells, two widely used gallbladder cancer cell lines. Additionally, treatment with baicalein inhibited the metastasis of GBC cells. Moreover, we demonstrated for the first time that baicalein inhibited GBC cell growth and metastasis via down-regulation of the expression level of Zinc finger protein X-linked (ZFX). In conclusion, our studies suggest that baicalein may be a potential phytochemical flavonoid for therapeutics of GBC and ZFX may serve as a molecular marker or predictive target for GBC.