ANALYSIS OF SURVIVAL BY TUMOR RESPONSE
ANALYSIS OF SURVIVAL BY TUMOR RESPONSE
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DOI：
10.1200/jco.1983.1.11.710
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发表时间：
1983-01-01
影响因子：
45.3
通讯作者：
GELBER, RD
中科院分区：
文献类型：
--
作者：
ANDERSON, JR;CAIN, KC;GELBER, RD
研究了在报告癌症化疗结果时比较应答者和无应答者生存率的常见做法。通常比较应答者和无应答者的方法偏向于应答者，这些结果经常被误解为提供了应答高于生存的证据，或者研究中的治疗有效。讨论了比较应答者和无应答者的两种有效方法，并提出了关于生存分析的建议。按缓解类别比较生存期可能有指导意义，但这种比较不应用于推断治疗有效性。
The common practice of comparing the survival of responders and nonresponders when reporting results of cancer chemotherapy treatment is investigated. The usual method of comparing responders and nonresponders is biased in favor of responders, and these results are frequently misinterpreted as providing evidence that response prolongs survival, or that the treatment under study in effective, Two valid methods for comparing responders and nonresponders are discussed and recommendations are made concerning the analysis of survival be response. A comparison of survival by response category may be useful descriptively, but such a comparison should not be used for inference concerning treatment effectiveness.