Metabolic control through glucocorticoid hormones: An update
Metabolic control through glucocorticoid hormones: An update
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DOI：
10.1016/j.mce.2013.03.007
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发表时间：
2013-11-05
影响因子：
4.1
通讯作者：
Herzig, Stephan
中科院分区：
文献类型：
--
作者：
Rose, Adam J.;Herzig, Stephan
在过去的几十年里，糖皮质激素(GC)及其同源的细胞内受体--糖皮质激素受体(GR)被认为是哺乳动物能量平衡的关键检查点。虽然健康营养代谢的许多方面都需要GC的生理水平和/或作用，但GC/GR信号的异常与严重的代谢功能障碍有关，包括肥胖、胰岛素抵抗和2型糖尿病。因此，GC信号轴内分子机制的研究已成为生物医学研究的主要焦点，最新的研究重点尤其是全身性血糖和脂质的处理。然而，随着新的高通量技术和更复杂的代谢表型能力的出现，GC的代谢功能最近被发现，包括GC/GR轴在蛋白质和胆汁酸动态平衡中的调节作用以及代谢器官间的通讯。因此，本文综述了GC/GR生物学的最新进展，并总结了与基础代谢研究和翻译代谢研究相关的结果。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
In the past decades, glucocorticoid (GC) hormones and their cognate, intracellular receptor, the glucocorticoid receptor (GR), have been well established as critical checkpoints in mammalian energy homeostasis. Whereas many aspects in healthy nutrient metabolism require physiological levels and/or action of GC, aberrant GC/GR signalling has been linked to severe metabolic dysfunction, including obesity, insulin resistance and type 2 diabetes. Consequently, studies of the molecular mechanisms within the GC signalling axis have become a major focus in biomedical research, up-to-date particularly focusing on systemic glucose and lipid handling. However, with the availability of novel high throughput technologies and more sophisticated metabolic phenotyping capabilities, as-yet non-appreciated, metabolic functions of GC have been recently discovered, including regulatory roles of the GC/GR axis in protein and bile acid homeostasis as well as metabolic inter-organ communication. Therefore, this review summarises recent advances in GC/GR biology, and summarises findings relevant for basic and translational metabolic research. (C) 2013 Elsevier Ireland Ltd. All rights reserved.