Recent examples of the use of biocatalysts with high accessibility and availability in natural product synthesis
Recent examples of the use of biocatalysts with high accessibility and availability in natural product synthesis
复制标题
DOI：
10.1016/j.tet.2018.05.053
复制
发表时间：
2018-07-05
期刊：
影响因子：
2.1
通讯作者：
Hanaya, Kengo
中科院分区：
文献类型：
--
作者：
Sugai, Takeshi;Higashibayashi, Shuhei;Hanaya, Kengo
本文综述了近年来在制备对映体富集起始原料和天然产物合成中间体中应用的高可及性和可获得性生物催化剂的应用情况（主要是2013-2017年）。主要内容有：1)有机化合物转化的生物催化剂的招募；2)制备规模生物催化合成实验的特殊注意事项；3)羰基底物的不对称还原；4)醇和羧酸对映体的动力学拆分；5)多功能醇和羧酸底物的不对称；6)识别远端和非中心手性。(C) 2018 Elsevier Ltd.版权所有。
Utilization of biocatalysts with high accessibility and availability, which have recently been applied in the preparation of enantiomerically enriched starting materials and synthetic intermediates for natural product syntheses (mainly 2013-2017) are summarized in this review. The main contents are as follows: 1) recruitment of biocatalysts for the transformation of organic compounds; 2) special precautions for preparative-scale biocatalytic synthetic experiments; 3) asymmetric reduction of carbonyl substrates; 4) kinetic resolution of alcohol and carboxylate enantiomers; 5) desymmetrization of multifunctional alcohol and carboxylate substrates; and 6) recognition of remote and non-central chirality. (C) 2018 Elsevier Ltd. All rights reserved.