Convergent Synthesis of the ent-ZA′B′C′D′-Ring System of Maitotoxin
Convergent Synthesis of the ent-ZA′B′C′D′-Ring System of Maitotoxin
复制标题
麦芽毒素ent-ZA′B′C′D′-环体系的收敛合成
DOI：
10.1021/acs.orglett.7b01301
复制
发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
Nakata Tadashi
中科院分区：
文献类型：
--
作者：
Saito Tatsuo;Morita Masayuki;Koshino Hiroyuki;Sodeoka Mikiko;Nakata Tadashi
利用ZA'-环烷基硼烷和C'D'-环(Z)-乙烯基碘的Suzuki-Miyaura交叉偶联反应，通过收敛策略完成了麦芽毒素的ent-ZA'B'C'D'-环系统的立体选择性合成，并随后通过还原O,S-缩醛构建B'-环。
Stereoselective synthesis of theent-ZA′B′C′D′-ring system of maitotoxin has been accomplished through a convergent strategy utilizing Suzuki–Miyaura cross coupling reaction of ZA′-ring alkylborane and C′D′-ring (Z)-vinyl iodide, and subsequent construction of the B′-ring by reduction of theO,S-acetal.