Effects of the (cid:1) 3-Adrenergic Receptor Agonist Disodium 5-[(2 R )-2-[[(2 R )-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL-316243) on Bladder Micturition Reflex in Spontaneously Hypertensive Rats
Effects of the (cid:1) 3-Adrenergic Receptor Agonist Disodium 5-[(2 R )-2-[[(2 R )-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL-316243) on Bladder Micturition Reflex in Spontaneously Hypertensive Rats
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(cid:1) 3-肾上腺素能受体激动剂二钠5-[(2R)-2-[[[(2R)-2-(3-氯苯基)-2-羟乙基]氨基]丙基]-1的作用，
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通讯作者：
R. Bottinelli
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作者：
M. Canepari;V. Agoni;L. Brocca;E. Ghigo;M. Gnesi;M. Minetto;R. Bottinelli
The present study investigated whether (cid:1) 3-adrenoceptor activation acts on the bladder afferent pathway by examination of the visceromotor reflex (VMR) and pressor responses to urinary bladder distension (UBD) and whether (cid:1) 3-adrenoceptor activation produces urinary bladder relaxation in hyperactive spon- taneously hypertensive rats (SHRs) in comparison with their normotensive control rats [Wistar-Kyoto (WKY)]. Using the VMR responses to noxious UBD as a measure of bladder afferent signal transmission, SHRs did not present a sensitized bladder phenotype. However, reduced bladder compliance accompanied by a reduced void threshold was detected in the SHR detrusor. Furthermore, the selective (cid:1) 3-adrenoceptor agonist disodium 5-[(2 R )-2-[[(2 R )-2-(3-chlorophenyl)-2-hydroxyethyl]- amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL-316243) (i.v.) failed to attenuate VMR or pressor responses to UBD in either SHRs or WKY rats, but it dose-dependently inhibited rhythmic contraction (RC) in SHRs. The minimal effective dose was 0.001 mg/kg. Using the same model in WKY rats, CL-316243 did not elicit significant inhibition of contractions in the bladder RC assay. These results suggest that SHRs represent abnormal efferent/ detrusor function (detrusor overactivity) without mechanosensory afferent hypersensitivity. The (cid:1) 3-adrenoceptor agonist CL-316243 acts on the detrusor muscle to increase urine storage in SHRs.
