Ovarian cancer stem cells: are they real and why are they important?
Ovarian cancer stem cells: are they real and why are they important?
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DOI：
10.1016/j.ygyno.2013.12.001
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发表时间：
2014-02
影响因子：
4.7
通讯作者：
Landen CN
中科院分区：
文献类型：
--
作者：
Shah MM;Landen CN
癌症干细胞假说已被提出作为描述异质性肿瘤中不同侵袭性水平的范例。具体而言，许多亚群已被清楚地证明在小鼠中具有增加的致瘤性、广泛的分化能力和对治疗的抗性。然而，目前尚不清楚这些实验结果在多大程度上具有潜在临床意义。这篇综述将描述这一新兴假说的原理，根据疾病的临床病程，它可能适用于卵巢癌的方式，以及我们如何利用它来改善卵巢癌患者的预后。
The cancer stem cell hypothesis has been put forward as a paradigm to describe varying levels of aggressiveness in heterogeneous tumors. Specifically, many subpopulations have been clearly demonstrated to possess increased tumorigenicity in mice, broad differentiating capacity, and resistance to therapy. However, it is still not clear the extent to which these experimental findings are potentially clinically significant. This review will describe the principles of this emerging hypothesis, ways in which it may be appropriate in ovarian cancer based on the clinical course of the disease, and how we might exploit it to improve outcomes in ovarian cancer patients.
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影响因子：
6.2
作者：
Alvero, Ayesha B.;Montagna, Michele K.;Chen, Rui;Kim, Ki Hyung;Kyungjin, Kim;Visintin, Irene;Fu, Han-Hsuan;Brown, David;Mor, Gil
通讯作者：
Mor, Gil
DOI：
10.1073/pnas.1220353110
发表时间：
2013-07-02
影响因子：
11.1
作者：
Humphries, Adam;Cereser, Biancastella;Graham, Trevor A.
通讯作者：
Graham, Trevor A.
影响因子：
3.7
作者：
Deng S;Yang X;Lassus H;Liang S;Kaur S;Ye Q;Li C;Wang LP;Roby KF;Orsulic S;Connolly DC;Zhang Y;Montone K;Bützow R;Coukos G;Zhang L
通讯作者：
Zhang L
影响因子：
3.9
作者：
Dou, Jun;Jiang, Cuilian;Gu, Ning
通讯作者：
Gu, Ning
影响因子：
4.7
作者：
Berek, JS;Markman, M;Hanjani, P
通讯作者：
Hanjani, P