Relationship of brain parenchyma within the caudal cranial fossa and ventricle size to syringomyelia in cavalier King Charles spaniels
Relationship of brain parenchyma within the caudal cranial fossa and ventricle size to syringomyelia in cavalier King Charles spaniels
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DOI：
10.1111/j.1748-5827.2010.00952.x
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发表时间：
2010-07-01
影响因子：
1.6
通讯作者：
Volk, H. A.
中科院分区：
文献类型：
--
作者：
Driver, C. J.;Rusbridge, C.;Volk, H. A.
方法：对59例合并CM的CKCS患者的磁共振图像进行回顾性分析，并将其分为SM组和非SM组。建立三维图像，计算颅窝、脑实质和脑室系统的体积，得出CCF、CCFP和V的百分比。如果存在空洞，则从其最大横宽开始测量空洞大小。结果：伴有SM的CKCS的CCFP(P=0中心点0001)和V(P=0中心点0002)显著高于无CCF的患者(P=0中心点925)。CCFP与空洞宽度呈正相关(Pearson r=0中心点437)，脑室大小与空洞宽度呈正相关(Spearman r=0中心点627)。临床意义：CCF过度拥挤与SM有关，这可能是CKCS合并CM时SM发生率高的原因。脑室和空洞大小之间的关联支持了SM的发展是脑脊液动力学改变的结果的理论。
Methods: Magnetic resonance images of 59 CKCS with CM were retrospectively reviewed and grouped with or without SM. Three-dimensional images were created and volumes of the fossae, brain parenchyma and ventricular system were calculated from which percentages of CCF, CCFP and V were created. If present, syrinx size was measured from its maximal transverse width. The percentages were statistically compared between groups, and correlation between percentages and syrinx dimensions was made.Results: CKCS with SM had significantly higher CCFP (P=0 center dot 0001) and V (P=0 center dot 0002) to those without but no significant difference in CCF (P=0 center dot 925). There was a positive correlation between CCFP and syrinx width (Pearson r=0 center dot 437) and ventricle size to syrinx width (Spearman r=0 center dot 627).Clinical Significance: A more marked overcrowding of the CCF is associated with SM, which may explain the high incidence of SM in CKCS with CM. The association between ventricle and syrinx dimensions supports the theory that SM development is the result of altered cerebrospinal fluid dynamics.