ISLET AMYLOID POLYPEPTIDE RESPONSE TO GLUCOSE, INSULIN, AND SOMATOSTATIN ANALOG ADMINISTRATION
ISLET AMYLOID POLYPEPTIDE RESPONSE TO GLUCOSE, INSULIN, AND SOMATOSTATIN ANALOG ADMINISTRATION
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DOI：
10.2337/diabetes.39.5.639
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发表时间：
1990-05-01
期刊：
影响因子：
7.7
通讯作者：
MATSUKURA, S
中科院分区：
文献类型：
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作者：
MITSUKAWA, T;TAKEMURA, J;MATSUKURA, S
我们测定了非糖尿病受试者血浆中胰岛淀粉样多肽(IAPP)对口服和静脉注射葡萄糖以及静脉注射胰岛素的反应。此外，我们还研究了生长抑素类似物SMS201-995对非糖尿病受试者葡萄糖诱导的IAPP分泌的影响。放射免疫法测定血浆IAPP浓度。口服75g葡萄糖(n=8)可显著提高血浆IAPP水平。0.7至14.0。+-。下午1点7分(P<；0.01)，给药60min。静脉注射10g葡萄糖(n=7)也引起血浆IAPP显著升高，从5.0±-。0.4至11.6+-注射后5分钟0.9 PM(P<；0.01)。血浆IAPP较治疗前显著下降(P<0.01)。0.4至2.9+-静脉注射胰岛素60min后(n=8)0.4(P<；0.01)。SMS201-995可完全阻断静脉注射葡萄糖引起的IAPP和胰岛素分泌。口服和静脉注射葡萄糖时血浆IAPP水平与胰岛素水平显著相关，胰岛素诱导低血糖时血浆IAPP水平与C-肽水平显著相关。这些结果表明，IAPP在葡萄糖负荷下与胰岛素协同分泌，IAPP的分泌受到低血糖和生长抑素的抑制。IAPP可能是一种新的控制碳水化合物代谢的胰腺激素。
We determined islet amyloid polypeptide (IAPP) response in plasma to oral and intravenous glucose administration and intravenous insulin injection in nondiabetic subjects. Moreover, we studied the effect of somatostatin analogue SMS 201-995 on glucose-induced IAPP secretion in nondiabetic subjects. Plasma IAPP concentration was determined by radioimmunoassay. Oral administration of 75 g glucose (n = 8) significantly increased plasma IAPP levels from 4.5 .+-. 0.7 to 14.0 .+-. 1.7 pM (P < 0.01) 60 min after administration. Intravenous administration of 10 g glucose (n = 7) also caused a significant increase in plasma IAPP from 5.0 .+-. 0.4 to 11.6 .+-. 0.9 pM (P < 0.01) 5 min after injection. Plasma IAPP significantly decreased from 5.1 .+-. 0.4 to 2.9 .+-. 0.4 pM (P < 0.01) 60 min after intravenous insulin injection (n = 8). Pretreatment with SMS 201-995 completely abolished IAPP and insulin secretion to intravenous glucose injection. A significant correlation was found between plasma IAPP and insulin levels in oral and intravenous glucose administration and between plasma IAPP and C-peptide levels during insulin-induced hypoglycemia. These results suggest that IAPP is cosecreted with insulin in response to a glucose load and secretion of IAPP is inhibited by hypoglycemia and somatostatin. IAPP may serve as a novel pancreatic hormone to control carbohydrate metabolism.