The postnatal development of spinal sensory processing
The postnatal development of spinal sensory processing
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DOI：
10.1073/pnas.96.14.7719
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发表时间：
1999-07-06
影响因子：
11.1
通讯作者：
Jennings, E
中科院分区：
文献类型：
--
作者：
Fitzgerald, M;Jennings, E
婴儿和儿童处理疼痛的机制应该在发育中的感觉神经系统的背景下看待。对发育中的大鼠脊髓背角感觉神经元的神经生理学特性和连通性的研究揭示了新生儿中枢神经系统分析皮肤无害和有害刺激的方式。新生脊髓背角细胞对单一重复性和持续性无害和有害输入的感受野特性和诱发活动受到发育调节，反映了脊髓内兴奋性传递的成熟。这些变化将对生后疼痛的加工产生重要影响。
The mechanisms by which infants and children process pain should be viewed within the context of a developing sensory nervous system. The study of the neurophysiological properties and connectivity of sensory neurons in the developing spinal cord dorsal horn of the intact postnatal rat has shed light on the way in which the newborn central nervous system analyzes cutaneous innocuous and noxious stimuli. The receptive field properties and evoked activity of newborn dorsal horn cells to single repetitive and persistent innocuous and noxious inputs are developmentally regulated and reflect the maturation of excitatory transmission within the spinal cord. These changes will have an important influence on pain processing in the postnatal period.