New screening method for lung cancer by detecting volatile organic compounds in breath
New screening method for lung cancer by detecting volatile organic compounds in breath
复制标题
DOI：
10.1007/s12094-007-0068-6
复制
发表时间：
2007-06-01
影响因子：
3.4
通讯作者：
Gonzalez Baron, M.
中科院分区：
文献类型：
--
作者：
Belda-Iniesta, C.;de Castro Carpeno, J.;Gonzalez Baron, M.
肺癌是世界上癌症相关死亡的常见原因。没有有效的筛查过程，这将其检测限制在晚期，因此死亡率很高。挥发性有机化合物 (VOC) 是人类呼吸中以气体形式存在的化合物（主要是细胞分解代谢的产物）。人们已经开发出不同的方法来分析挥发性有机化合物并在健康受试者和肺癌患者中进行比较。在这篇综述中，我们总结了用于分析 VOC 的不同技术。许多报告已发表，其结果与采用公认的筛查方法（如乳房X线照相术）所取得的结果相似。这些方法为肺癌筛查展现了良好的前景。
Lung cancer is a frequent cause of cancer-related deaths in the world. There is no valid screening process and this limits its detection to the late stages, with consequently high mortality rates. Volatile organic compounds (VOC) are chemical compounds (mainly the products of cell catabolism) found as gases in the human breath. Different methods have been developed to analyse VOCs and to compare them in healthy subjects and lung cancer patients. In this review, we summarise the different techniques used to analyse VOC. Many reports have been published with promising results similar to those achieved with accepted screening methods such as mammography. These methods show good perspectives on lung cancer screening.