B-cell anergy: from transgenic models to naturally occurring anergic B cells?
B-cell anergy: from transgenic models to naturally occurring anergic B cells?
复制标题
DOI：
10.1038/nri2133
复制
发表时间：
2007-08-01
影响因子：
100.3
通讯作者：
Vilen, Barbara J.
中科院分区：
文献类型：
--
作者：
Cambier, John C.;Gauld, Stephen B.;Vilen, Barbara J.
Anergy, a condition in which cells persist in the periphery but are unresponsive to antigen, is responsible for silencing many self-reactive B cells. Loss of anergy is known to contribute to the development of autoimmune diseases, including systemic lupus erythematosus and type 1 diabetes. Multiple transgenic mouse models have enabled the dissection of mechanisms that underlie anergy, and recently, anergic B cells have been identified in the periphery of wild-type mice. Heterogeneity of mechanistic concepts developed using model systems has complicated our understanding of anergy and its biological features. In this Review, we compare and contrast the salient features of anergic B cells with a view to developing unifying mechanistic hypotheses that explain their lifestyles.
