Use of Mono Mac 6 human monocytic cell line and J774 murine macrophage cell line in parallel antimycobacterial drug studies.
Use of Mono Mac 6 human monocytic cell line and J774 murine macrophage cell line in parallel antimycobacterial drug studies.
复制标题
在平行抗分枝杆菌药物研究中使用 Mono Mac 6 人单核细胞系和 J774 鼠巨噬细胞系。
DOI：
10.1128/aac.40.9.2206
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Barrow,WW
中科院分区：
文献类型：
--
作者：
Wright,EL;Quenelle,DC;Suling,WJ;Barrow,WW
The Mono Mac 6 (MM6) human monocytic cell line was evaluated with the established J774 murine macrophage cell line to ascertain its effectiveness in determining the intracellular activities of antimycobacterial drugs. Cells were infected with Mycobacterium tuberculosis H37Ra and treated with drug concentrations corresponding to the MICs, as well as to threefold higher than and threefold less than the MICs. Changes in CFU were compared after 7 days to determine significant differences between treated and nontreated groups. The results suggest that MM6 will make a useful model for testing the intracellular activities of antituberculosis drugs.
