One-pot three-component synthesis of α-iminonitriles by IBX/TBAB-Mediated oxidative Strecker reaction
One-pot three-component synthesis of α-iminonitriles by IBX/TBAB-Mediated oxidative Strecker reaction
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DOI：
10.1021/ol800199b
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发表时间：
2008-04-17
期刊：
影响因子：
5.2
通讯作者：
Zhu, Jieping
中科院分区：
文献类型：
--
作者：
Fontaine, Patrice;Chiaroni, Angele;Zhu, Jieping
The reaction of aldehydes, amines, and TMSCN in the presence of 2-iodoxybenzoic acid (IBX) and tetrabutylammonium bromide (TBAB) afforded alpha-iminonitriles in good to excellent yields under mild conditions. The presence of TBAB is essential for this transformation. The methodology was applied to a two-step synthesis of indolizidine via a microwave-assisted intramolecular cycloaddition of alpha-iminonitrile.
