Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese
Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese
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DOI：
10.1507/endocrj.ej13-0369
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发表时间：
2014-02-01
影响因子：
2
通讯作者：
Wang, Ji-Guang
中科院分区：
文献类型：
--
作者：
Li, Li-Hua;Yin, Xue-Yan;Wang, Ji-Guang
以前的研究已经确定了VDR，GC和CYP2R1中的几种常见遗传变异与西方人群中25-羟基维生素D [25（OH）D]和维生素D缺乏症的循环水平相关。我们的目的是调查这些变异与血清25（OH）D水平和维生素D状态的1，199名中国人。采用多重SNaPshot法对VDR、GC和CYP2R1的9种常见变异体进行基因分型，放射免疫法检测血清25（OH）D。维生素D缺乏症的患病率（
Previous studies have identified several common genetic variants in VDR, GC and CYP2R1 to be associated with circulating levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D deficiency in Western populations. We aimed to investigate the associations of these variants with serum levels of 25(OH)D and vitamin D status in 1,199 Chinese. Nine common variants of VDR, GC and CYP2R1 were genotyped using multiple SNaPshot assay, and serum 25(OH)D was detected by radioimmunoassay. The prevalence of vitamin D deficiency (