Computed Tomography in Nonalcoholic Fatty Liver Disease
Computed Tomography in Nonalcoholic Fatty Liver Disease
复制标题
非酒精性脂肪肝的计算机断层扫描
DOI：
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发表时间：
2006
影响因子：
3.1
通讯作者：
N. Tözün
中科院分区：
文献类型：
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作者：
D. Duman;Ç. Çelikel;D. Tüney;N. Imeryüz;E. Avşar;N. Tözün
计算机断层扫描 (CT) 在评估肝脂肪变性中的价值和/或局限性在非酒精性脂肪性肝病 (NAFLD) 中尚未得到充分研究。我们前瞻性评估了 CT 在评估 NAFLD 患者肝脂肪变性数量方面的准确性以及人口统计和组织病理学变量对 CT 图像的影响。四十名经活检证实患有 NAFLD 的患者符合资格。其中，10 例表现出肝铁过载。获得肝脏和脾脏的衰减测量值，并计算脾-肝脏衰减差（ΔS-LA）。观察到 ΔS–LA 与病理性肝脂肪变性之间存在良好的相关性（r = 0.837，P < 0.0001）。尽管铁超负荷患者的平均 ΔS–LA 显着较低，但肝铁超负荷并不影响这种相关性。未检测到 ΔS–LA 与肝脏炎症、纤维化或体重指数之间的相关性。我们的结论是，CT 得出的 ΔS–LA 可能是预测 NAFLD 患者肝脂肪变性数量的有用工具，因为它不受各种个体因素的影响。
The value and/or limitations of computed tomography (CT) in assessment of hepatosteatosis are not well studied in nonalcoholic fatty liver disease (NAFLD). We prospectively evaluated the accuracy of CT in assessing the amount of hepatosteatosis in NAFLD patients and the impact of demographic and histopathologic variables on CT images. Forty patients with biopsy-proven NAFLD were eligible. Of these, 10 exhibited hepatic iron overload. Liver and spleen attenuation measurements were obtained and spleen-minus-liver attenuation difference (ΔS–LA) was calculated. A good correlation between ΔS–LA and pathological hepatosteatosis was observed (r = 0.837, P < 0.0001). Liver iron overload did not affect this correlation, although the mean ΔS–LA was significantly lower in patients with iron overload. No correlation was detected between ΔS–LA and hepatic inflammation, fibrosis, or body mass index. We conclude that ΔS–LA derived from CT may be a useful tool for predicting the amount of hepatosteatosis in NAFLD patients as it is not affected by various individual factors.
影响因子：
25.7
作者：
Bonkovsky, HL;Jawaid, Q;Banner, BF
通讯作者：
Banner, BF