Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride.
Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride.
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DOI：
10.1016/j.etap.2015.08.007
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发表时间：
2015-09
影响因子：
4.3
通讯作者：
R. Niu;Jianming Wang;Zilong Sun;X. Xue;Xiaoyan Yan;Jinming Wang;Jianhai Zhang;Jundong Wang
中科院分区：
文献类型：
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作者：
R. Niu;Jianming Wang;Zilong Sun;X. Xue;Xiaoyan Yan;Jinming Wang;Jianhai Zhang;Jundong Wang
众所周知，氟是一种广泛存在的天然污染物，它天然存在于土壤、水、食物和各种牙科护理产品中。美国国家研究委员会指出，目前，数以百万计的人在饮用水中暴露在高氟环境中，特别是在中国、印度和墨西哥(Doull等人，2006年)。例如，根据官方数据，中国有28个省的9,200万居民患有氟中毒(中国新闻，2012年)。在印度，有6000万人生活在氟中毒流行地区的20个邦(Saxena等人，2012年)，墨西哥有600多万居民生活在风险地区(Hurtado和Gardea-Torresdey，2004年)。氟中毒被认为是世界范围内的公共卫生问题。F的生殖毒性已被流行病学和实验室研究证实，高氟暴露对精子发生(Pushpalatha等人，2005)、精子形态和活动度(Spitle，2009)、精子过度激活(Sun等人，2011)、精子受精能力(Dvoráková-Hortováet al.，2008)以及生殖激素分泌(Ortiz-Pérez et al.，2003，Susheela and Jethanandani，1996)产生不利影响。生殖激素，包括睾酮(T)、卵泡刺激素(FSH)和黄体生成素(LH)，是睾丸雄激素和正常精子发生所必需的。周等人。研究发现，摄入氟显著降低雌性大鼠的FSH、LH、T、孕酮(P)和雌二醇(E2)浓度(周等人，2013年)，这一发现得到了其他大鼠研究结果的支持(Ghosh等人，2002年，Sarkar等人，2006年)。众所周知，这些激素的分泌依赖于下丘脑-垂体的调节和睾丸类固醇的生成。然而，下丘脑-垂体-睾丸(HPT)轴上的哪些组织、激素和关键酶与F诱导的生殖功能障碍的机制仍不清楚。
It is well known that fluoride (F) is a widespread natural pollutant, which naturally exists in soil, water, food, and various kinds of dental care products. US National Research Council points out that at present, millions of people are exposed to high F in their drinking water, especially in China, India, and Mexico (Doull et al., 2006). For example, according to the official data, there are 92 million residents with fluorosis in 28 provinces in China (China News, 2012). In India, 60 million people live in 20 states in endemic areas of fluorosis (Saxena et al., 2012), and more than 6 million inhabitants in risk areas in Mexico (Hurtado and Gardea-Torresdey, 2004). Fluorosis is considered to be a public health issue in world. Besides bone and tooth, non-hard tissues are also the toxic targets of F.The reproductive toxicity of F has been confirmed by epidemiological and laboratory studies, which showed that spermatogenesis (Pushpalatha et al., 2005), sperm morphology and motility (Spittle, 2009), sperm hyperactivation (Sun et al., 2011), sperm fertilizing ability (Dvoráková-Hortová et al., 2008), and reproductive hormones secretion (Ortiz-Pérez et al., 2003, Susheela and Jethanandani, 1996) were adversely affected by high F exposure. Reproductive hormones, including testosterone (T), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), are required for testicular androgenesis and normal spermatogenesis. Zhou et al. found that F ingestion significantly lowered the concentration of FSH, LH, T, progesterone (P), and estradiol (E 2) in female rats (Zhou et al., 2013), which was supported by results from other studies on rats (Ghosh et al., 2002, Sarkar et al., 2006). It is well known that the secretion of these hormones relies on both hypothalamic-pituitary regulation and testicular steroidogenesis. However, which tissues, hormones, and key enzymes in hypothalamic-pituitary-testicular (HPT) axis were associated with the mechanism of F-induced reproductive dysfunction remains largely unknown.