UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response.
UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response.
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紫外线照射诱导的白细胞介素-1 和碱性成纤维细胞生长因子的合成和释放介导了紫外线反应的一部分。
DOI：
10.1016/s0021-9258(18)53311-1
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Hans J. RahmsdorfS
中科院分区：
文献类型：
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作者：
Marcus Kramer;C. Sachsenmaier;Peter Herrlich;Hans J. RahmsdorfS
UV照射的细胞向培养基中释放因子，当给予未照射的细胞时，这些因子诱导几种UV诱导基因（胶原酶I、人类免疫缺陷病毒1型、金属硫蛋白IIA）的转录。我们在这里确定从紫外线处理的HeLa细胞释放的活性因子，如白细胞介素1 α和碱性成纤维细胞生长因子。紫外线照射导致这两种因子的mRNA水平增加，并增强其合成。用抑制生长因子-生长因子受体相互作用的药物苏拉明和针对白细胞介素1 α和碱性成纤维细胞生长因子的抗体进行的实验表明，生长因子不仅将紫外线诱导的信号传递给未照射的细胞，而且作用于生产细胞，从而为至少部分紫外线反应建立了一个强制性的生长因子环。
UV irradiated cells release into the culture medium factors that induce, when given to nonirradiated cells, the transcription of several UV-inducible genes (collagenase I, human immunodeficiency virus type 1, metallothionein IIA). We identify here the active factors released from UV-treated HeLa cells, as interleukin 1 alpha and basic fibroblast growth factor. UV irradiation leads to increased mRNA levels for both factors and to their enhanced synthesis. Experiments with the drug suramin, which inhibits growth factor-growth factor receptor interactions and with antibodies directed against interleukin 1 alpha and basic fibroblast growth factor, suggest that growth factors do not only transduce the UV-induced signal to nonirradiated cells but act on the producer cell thus establishing an obligatory growth factor loop for at least part of the UV response.