Successful treatment of a left ventricular assist device infection with daptomycin non-susceptible methicillin-resistant Staphylococcus aureus: case report and review of the literature.
Successful treatment of a left ventricular assist device infection with daptomycin non-susceptible methicillin-resistant Staphylococcus aureus: case report and review of the literature.
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达托霉素不敏感耐甲氧西林金黄色葡萄球菌成功治疗左心室辅助装置感染：病例报告和文献综述。
DOI：
10.1111/j.1399-3062.2012.00775.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Ostrowsky,B
中科院分区：
文献类型：
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作者：
Levy,DT;Steed,ME;Rybak,MJ;Guo,Y;Gialanella,P;Hanau,L;Muggia,V;Ostrowsky,B
左心室辅助装置（LVAD）的接受者极易发生多药耐药（MDR）微生物感染。我们描述了一例LVAD患者发生器械相关、达托霉素非敏感、甲氧西林耐药金黄色葡萄球菌感染的病例，强调该患者人群极易发生此类抗菌药物耐药性。本报告包括对达托霉素非敏感性发展机制的文献进行了全面综述，并提出了预防其出现的方法。我们还提供并强调了在试图控制此类耐药分离株感染时应遵守的适当指南。该病例还证明了LVAD切除和移植作为侵入性LVAD感染适当管理的组成部分的确定性治疗的重要性。此外，我们认为即使是MDR微生物感染也可能不会对移植后结局产生不利影响。
Recipients of left ventricular assist devices (LVADs) are highly susceptible to the development of infections with multidrug‐ resistant (MDR) organisms. We describe the case of a patient with an LVAD who developed a device‐related, daptomycin non‐susceptible, methicillin‐resistantStaphylococcus aureusinfection, highlighting this patient population as highly vulnerable to the development of such antimicrobial resistance. This report includes a thorough review of the literature on the mechanisms of development of daptomycin non‐susceptibility and suggests ways to prevent its emergence. We also provide and underscore the appropriate guidelines to abide by when attempting to control infections with such resistant isolates. This case also demonstrates the importance of definitive treatment with LVAD removal and transplantation as a component of appropriate management of invasive LVAD infections. In addition, we suggest that even infections with MDR organisms may not adversely affect post‐transplant outcomes.