A case of radiation recall mucositis associated with docetaxel
A case of radiation recall mucositis associated with docetaxel
复制标题
DOI：
10.1002/hed.10352
复制
发表时间：
2004-02-01
影响因子：
2.9
通讯作者：
Sanguineti, G
中科院分区：
文献类型：
--
作者：
Culp, LR;Pou, AM;Sanguineti, G
背景。放射回忆反应，特别是皮炎，在文献中有详细记载。然而，放射回忆性粘膜炎是一种罕见的临床现象。方法。我们报告一例 45 岁男性，被诊断患有舌根鳞状细胞癌。他接受了手术治疗，随后进行了化疗和放射治疗。完成治疗几个月后，他在之前接受照射的区域外出现了复发。他接受了与多西他赛同时进行的放射治疗作为挽救治疗。结果。在抢救治疗期间，他出现了与之前受辐射区域相对应的急性回忆性粘膜炎。他停止了多西紫杉醇化疗，他的症状迅速改善。结论。该病例描述了与多西他赛相关的放射回忆性粘膜炎，这是一种罕见但可能严重的临床情况。考虑到该反应的潜在严重性以及多西紫杉醇作为复发性头颈癌二线治疗的使用不断增加，了解这种现象非常重要。 (C) 2004 年 Wiley 期刊公司。
Background. Radiation recall reactions, in particular dermatitis, are well documented in the literature. However, radiation recall mucositis is a rare clinical phenomenon.Methods. We report a case of a 45-year-old man diagnosed with squamous cell carcinoma of the base of tongue. He was treated with surgery followed by chemotherapy and radiation therapy. Several months after completing treatment, he had a recurrence develop outside of the previously irradiated field. He was offered radiation therapy concurrent with docetaxel as salvage therapy.Results. During salvage therapy, acute recall mucositis developed corresponding to his previously irradiated fields. His chemotherapy with docetaxel was withheld, and his symptoms rapidly improved.Conclusions. This case describes radiation recall mucositis associated with docetaxel, a rare but potentially serious clinical situation. Given the potential severity of the reaction and increasing use of docetaxel as second-line treatment of recurrent head and neck cancers, it is important to be aware of this phenomenon. (C) 2004 Wiley Periodicals, Inc.