Examining five-and ten-year survival in older women with breast cancer using cancer-specific geriatric assessment
Examining five-and ten-year survival in older women with breast cancer using cancer-specific geriatric assessment
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DOI：
10.1016/j.ejca.2011.06.016
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发表时间：
2012-04-01
影响因子：
8.4
通讯作者：
Silliman, Rebecca A.
中科院分区：
文献类型：
--
作者：
Clough-Gorr, Kerri M.;Thwin, Soe Soe;Silliman, Rebecca A.
目的：研究5年和10年的生存率的基础上癌症特异性老年评估（C-SGA）在老年妇女与早期阶段breastcancer.Methods：我们评估了660名妇女>= 65岁诊断为I-IIIA期原发性乳腺癌和主治医生的许可，在四个地理区域在美国（USA）。数据收集超过十年的后续行动，从同意妇女的医疗记录，电话采访，国家死亡指数和社会保障死亡指数。C-SGA由四个领域使用六项指标描述：社会人口统计学（财政资源）;临床（合并症，肥胖）;功能（身体功能限制）;和心理社会（一般心理健康，社会支持）。评估了不同C-SGA域缺陷受试者组的全因死亡率和乳腺癌特异性死亡率以及接受指南推荐治疗的生存率（截止值>= 3个缺陷）。C-SGA缺陷≥ 3的女性存活10年的比例在统计学上一直显著较低（全因26% vs 46%，乳腺癌特异性76% vs 89%，p = 3，即使完全校正混杂因素后C-SGA缺陷（HR 5-yAllCauseFullyAdjusted = 1.87 [1.36-2.57]，HR10（-yrAllCauseFullyAdjusted）= 1.74 [1.35-2.15]，HR5-（乳腺癌完全校正后的年）= 1.95 [1.18-3.20]，HR 10-（yrBreastCancerFullyAdjusted）= 1.99 [1.21-3.28]）。结论：无论年龄和疾病阶段如何，C-SGA预测老年妇女的5年和10年全因和乳腺癌特异性生存率。因此，C-SGA可以提供一种有效的策略来指导治疗决策，并确定干预的风险因素。(C)2011爱思唯尔有限公司保留所有权利。
Purpose: To examine five-and ten-year survival based on cancer-specific geriatric assessment (C-SGA) in older women with early stage breast cancer.Methods: We evaluated 660 women >= 65-years old diagnosed with stage I-IIIA primary breast cancer and attending physician permission to contact in four geographic regions in the United States of America (USA). Data were collected over ten-years of follow-up from consenting women's medical records, telephone interviews, National Death Index and Social Security Death Index. C-SGA was described by four domains using six measures: socio-demographic (financial resources); clinical (comorbidity, obesity); function (physical function limitations); and psychosocial (general mental health, social support). Survival from all-cause and breast-cancer-specific mortality and receipt of guideline-recommended therapy was assessed for different groups of subjects with C-SGA domain deficits (cut-off >= 3 deficits).Results: The proportion of women with >= 3 C-SGA deficits surviving ten-years was consistently statistically significantly lower (all-cause 26% versus 46% and breast-cancer-specific 76% versus 89%, p = 3 C-SGA deficits even when fully adjusted for confounding factors (HR5-yrAllCauseFullyAdjusted = 1.87 [1.36-2.57], HR10(-yrAllCauseFullyAdjusted) = 1.74 [1.35-2.15], HR5-(yrBreastCancerFullyAdjusted) = 1.95 [1.18-3.20], HR10-(yrBreastCancerFullyAdjusted) = 1.99 [1.21-3.28]).Conclusion: Regardless of age and stage of disease, C-SGA predicts five-and ten-year all-cause and breast-cancer-specific survival in older women. Hence, C-SGA may provide an effective strategy to guide treatment decision-making and to identify risk factors for intervention. (C) 2011 Elsevier Ltd. All rights reserved.