Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism
Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism
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DOI：
10.1182/blood-2004-08-3328
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发表时间：
2005-02-15
期刊：
影响因子：
20.3
通讯作者：
Salama, A
中科院分区：
文献类型：
--
作者：
Hoppe, B;Tolou, F;Salama, A
已知因子7活化蛋白酶（FSAP）变异马尔堡I在体外可以减弱纤溶系统，最近被证明是颈动脉狭窄演变和进展的重要预测因子。本病例对照研究的目的是评估FSAP马尔堡I型在静脉血栓栓塞（VTE）发生中的作用。与健康对照组（213例对照5例，2.3%）相比，有WE病史的患者（213例患者中有117例，8.0%,P = 0.014）或特发性WE患者（103例患者中有12例，11.7%,P = 0.002）发生FSAP马尔堡I型的频率显著增加。Logistic回归分析证实，FSAP马尔堡I型是WE（优势比为3.5；95%可信区间[CI]为1.2-10.0）和特发性WE（优势比为6.2；95% CI为2.0-18.9）的独立危险因素。(C) 2005年由美国血液病学会出版。
The factor VII-activating protease (FSAP) variant Marburg I is known to attenuate the profibrinolytic system in vitro and was recently shown to be a significant predictor for the evolution and progression of carotid stenosis. The objective of this case-control study was to assess FSAP Marburg I's role in the occurrence of venous thromboembolism (VTE). The frequency of FSAP Marburg I was significantly increased in patients with a history of WE (117 of 213 patients, 8.0%, P = .014) or idiopathic WE (12 of 103 patients, 11.7%, P = .002) compared to healthy controls (5 of 213 controls, 2.3%). Logistic regression analysis confirmed FSAP Marburg I to be an independent risk factor for WE (odds ratio, 3.5; 95% confidence interval [CI], 1.2-10.0) and idiopathic WE (odds ratio, 6.2; 95% CI, 2.0-18.9). (C) 2005 by The American Society of Hematology.