Measuring quantitative serum human chorionic gonadotropin. Variations in levels between kits.
Measuring quantitative serum human chorionic gonadotropin. Variations in levels between kits.
复制标题
定量测定血清人绒毛膜促性腺激素。
DOI：
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发表时间：
1995
影响因子：
0.2
通讯作者：
G. Hankins
中科院分区：
文献类型：
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作者：
C. Smikle;K. Sorem;F. Wians;G. Hankins
人绒毛膜促性腺激素（hCG）可用于监测早期妊娠。它还可用作妊娠滋养细胞疾病、绒毛膜癌和睾丸癌的诊断和随访的肿瘤标志物。母体血清非结合雌三醇、甲胎蛋白和定量 hCG 的组合已显示出作为唐氏综合症产前筛查的前景。在 hCG 的定量评估中，各种试剂盒使用的校准品均按照世界卫生组织分别于 1968 年和 1975 年制定的第二国际标准或第一国际参考制剂 (IRP) 中的一个进行标准化。 IRP 现在被认为是第三个国际标准，并且两个术语可以互换使用。如果比较或同时使用不同实验室使用不同标准的测定确定的定量 hCG 水平，则在临床情况中可能存在混乱。建议从业人员了解其实验室使用哪种校准标准，并相应地解释结果。
Human chorionic gonadotropin (hCG) may be used in the monitoring of early pregnancy. It may also be used as a tumor marker in the diagnosis and follow-up of gestational trophoblastic disease, choriocarcinoma and testicular carcinoma. The combination of maternal serum unconjugated estriol, alpha-fetoprotein and quantitative hCG has shown promise as an antepartum screen for Down syndrome. In the quantitative assessment of hCG, the calibrators used by various kits are standardized to one of two different standards, either the Second International Standard or the First International Reference Preparation (IRP), established by the World Health Organization in 1968 and 1975, respectively. The IRP is now considered the Third International Standard, and both terms may be used interchangeably. Confusion may exist in clinical situations if quantitative hCG levels determined by assays in different laboratories using different standards are compared or used simultaneously. Practitioners are advised to be aware of which calibration standard is utilized in their laboratory and to interpret the results accordingly.