Facile and highly selective conversion of nitriles to amides via indirect acid-catalyzed hydration using TFA or AcOH-H2SO4
Facile and highly selective conversion of nitriles to amides via indirect acid-catalyzed hydration using TFA or AcOH-H2SO4
复制标题
DOI：
10.1021/jo048240a
复制
发表时间：
2005-03-04
影响因子：
3.6
通讯作者：
Singhal, N
中科院分区：
文献类型：
--
作者：
Moorthy, JN;Singhal, N
以TFA-H2SO4混合物为试剂体系，通过间接酸催化水化反应，在1-8 h内，脂肪族和芳香族腈均可方便、选择性地一步转化为相应的酰胺。虽然相同的试剂对位阻腈（如甲腈）不起作用，但可以通过在更高的温度（bb0 - 90℃）下将TFA转化为AcOH来完成。
Both aliphatic and aromatic nitriles are conveniently and selectively converted in a single step, via an indirect acid-catalyzed hydration, into the corresponding amides in 1-8 h using a TFA-H2SO4 mixture as a reagent system. Although the same reagent did not work for the sterically hindered nitriles such as mesitonitrile, the transformation could be accomplished by changing TFA to AcOH at higher temperatures (>90 degreesC).