Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection.
Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection.
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DOI：
10.1084/jem.165.4.1212
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发表时间：
1987-04-01
期刊：
影响因子：
--
通讯作者：
Bennett M
中科院分区：
文献类型：
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作者：
Murphy WJ;Kumar V;Bennett M
C.B-17SCID(H-2d)小鼠是导致严重联合免疫缺陷(SCID)的基因的纯合子。这些小鼠没有T或B细胞功能，但表现出正常的自然杀伤(NK)活性。受照的SCID小鼠接受骨髓移植，以确定抗体是否对同种异体骨髓移植排斥反应是必需的。SCID小鼠排斥H-2/HH-1异基因骨髓移植。此外，这种排斥能力可以使用SCID骨髓作为NK祖细胞的来源输入受照射的B6(H-2b)宿主。我们得出结论，在没有免疫球蛋白的情况下，NK细胞可以介导同种异体骨髓移植的反应性。由此可见，NK细胞可能具有HH抗原的特异性受体。
C.B-17 scid (H-2d) mice are homozygous for the gene that causes severe combined immune deficiency (SCID). These mice have no T or B cell function, yet display normal natural killer (NK) activity. Irradiated SCID mice were challenged with marrow grafts to determine if antibodies are necessary for marrow allograft rejection. SCID mice rejected H-2/Hh- 1 allogeneic marrow grafts. Moreover, this rejection capability could be adoptively transferred using SCID marrow as a source of NK progenitors infused into irradiated B6 (H-2b) hosts. We conclude that NK cells can mediate marrow allograft reactivity in the absence of immunoglobulin. It follows that NK cells probably have specific receptors for Hh antigens.