Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses.
Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses.
复制标题
DOI：
10.1084/jem.191.1.129
复制
发表时间：
2000-01-03
期刊：
影响因子：
--
通讯作者：
Kärre K
中科院分区：
文献类型：
--
作者：
Glas R;Franksson L;Une C;Eloranta ML;Ohlén C;Orn A;Kärre K
自然杀伤细胞（NK）可以自发地溶解某些病毒感染和转化的细胞。然而，在免疫反应的早期，NK细胞被进一步激活并招募到组织部位，在那里它们发挥效应功能。这一过程依赖于细胞因子，但是否受NK细胞对易感靶细胞的识别调控尚不清楚。我们在这里表明，活化的NK细胞浸润到腹膜腔以响应肿瘤细胞是由肿瘤主要组织相容性复合体（MHC） I类表型控制的。缺乏适当MHC I类表达的肿瘤细胞诱导NK细胞浸润、细胞毒性激活和诱导NK细胞中干扰素γ的转录。这些反应的诱导被肿瘤细胞MHC I类表达的恢复所抑制。在每个细胞的基础上，NK细胞对MHC i类缺陷肿瘤细胞的反应活性是内源性NK细胞的10倍。虽然这些效应细胞表现出典型的NK特异性，它们优先杀死MHC i类缺陷细胞，但在诱导腹腔内反应时，这种特异性更加明显。本文讨论了与NK反应可能的适应性成分相关的观察结果，即只有NK细胞才能中和的挑战的招募/激活。
Natural killer (NK) cells can spontaneously lyse certain virally infected and transformed cells. However, early in immune responses NK cells are further activated and recruited to tissue sites where they perform effector functions. This process is dependent on cytokines, but it is unclear if it is regulated by NK cell recognition of susceptible target cells. We show here that infiltration of activated NK cells into the peritoneal cavity in response to tumor cells is controlled by the tumor major histocompatibility complex (MHC) class I phenotype. Tumor cells lacking appropriate MHC class I expression induced NK cell infiltration, cytotoxic activation, and induction of transcription of interferon γ in NK cells. The induction of these responses was inhibited by restoration of tumor cell MHC class I expression. The NK cells responding to MHC class I–deficient tumor cells were ∼10 times as active as endogenous NK cells on a per cell basis. Although these effector cells showed a typical NK specificity in that they preferentially killed MHC class I–deficient cells, this specificity was even more distinct during induction of the intraperitoneal response. Observations are discussed in relation to a possible adaptive component of the NK response, i.e., recruitment/activation in response to challenges that only NK cells are able to neutralize.
登录
查看更多内容
影响因子：
64.8
作者：
Fan, QR;Mosyak, L;Wiley, DC
通讯作者：
Wiley, DC
DOI：
10.1084/jem.174.2.479
发表时间：
1991-08-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Basse P;Herberman RB;Nannmark U;Johansson BR;Hokland M;Wasserman K;Goldfarb RH
通讯作者：
Goldfarb RH
影响因子：
64.8
作者：
BIX, M;LIAO, NS;RAULET, D
通讯作者：
RAULET, D
DOI：
10.1073/pnas.87.7.2725
发表时间：
1990-04-01
影响因子：
11.1
作者：
GILLILAND, G;PERRIN, S;BUNN, HF
通讯作者：
BUNN, HF
DOI：
10.1084/jem.175.3.843
发表时间：
1992-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Glas R;Sturmhöfel K;Hämmerling GJ;Kärre K;Ljunggren HG
通讯作者：
Ljunggren HG