Biogenetic proposals and blosynthetic studies on secondary metabolites of opisthobranch molluscs
Biogenetic proposals and blosynthetic studies on secondary metabolites of opisthobranch molluscs
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DOI：
10.1007/978-3-540-30880-5_14
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Fontana, A.
中科院分区：
文献类型：
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作者：
Fontana, A.
海洋化学多样性是由大量的变化产生的，这些变化在陆地化学多样性中往往没有注意到。海洋生物在大多数方面与陆地生物不同，我们对海洋生物的遗传学和生物化学的了解仍然非常有限，仅限于少数物种。因此，生物合成研究和生物遗传学推测对于预测相关酶及其编码基因至关重要，以期为合理改造海洋天然产品创造条件。确定生物合成途径的另一个有用成果是对自然产品进行分类，这有助于将化学多样性与生物多样性联系起来。本文综述了海洋后鳃类生物次生代谢产物的生物成因，已成为一个丰富的来源，具有广泛的生物活性的结构多样的代谢产物。
Marine chemical diversity is generated by a large number of transformations often not noted in terrestrial counterparts. Life in the oceans differs in most respects from life on land and our knowledge of the genetics and biochemistry of marine organisms is still very limited to a small number of species. Biosynthetic studies and biogenetic speculations can therefore be crucial in predicting relevant enzymes and their encoding genes, with a view to setting the stage for rational engineering of marine natural products. A further useful outcome to the identification of biosynthetic pathways is the resulting classification of natural products, which can serve to correlate chemical diversity and biodiversity. This review summarizes the present knowledge on secondary metabolites biogenesis in marine opisthobranchs, a class of organisms that has been emerging as a prolific source of structurally diverse metabolites possessing a broad variety of biological activities.