Modulation of luteinizing hormone release and catecholamine activity by opiates in the female rat.
Modulation of luteinizing hormone release and catecholamine activity by opiates in the female rat.
复制标题
阿片类药物对雌性大鼠黄体生成素释放和儿茶酚胺活性的调节。
DOI：
10.1159/000123899
复制
发表时间：
1984
影响因子：
4.1
通讯作者：
Crowley,WR
中科院分区：
文献类型：
--
作者：
Adler,BA;Crowley,WR
以前的研究表明，阿片受体阻滞剂纳洛酮对黄体生成素释放的刺激可以被儿茶酚胺合成抑制剂阻止，提示阿片对儿茶酚胺释放的调节。本研究测试了阿片激动剂和拮抗剂是否会影响合成抑制后观察到的下丘脑儿茶酚胺的耗竭，作为衡量儿茶酚胺活性的指标，并伴随着促黄体生成素分泌的变化。给雌激素性刺激的大鼠注射纳洛酮可增加黄体生成素的释放，增强下丘脑视前-前部和下丘脑内侧基底核去甲肾上腺素的耗竭，增强下丘脑内侧基底区肾上腺素和多巴胺的下降，提示这些区域的儿茶酚胺活性增加。给雌鼠注射阿片激动剂吗啡可降低黄体生成素水平，减少上述脑区儿茶酚胺的消耗，表明活动减少。在大多数情况下，纳洛酮可拮抗吗啡的抑制作用。这些发现表明，纳洛酮可能通过促进下丘脑儿茶酚胺的代谢来刺激黄体生成素的释放，可能是通过消除内源性阿片神经肽的抑制影响。
Previous studies have shown that the stimulation of LH release by the opiate receptor blocker, naloxone, can be prevented by catecholamine synthesis inhibitors, suggesting opiate regulation of catecholamine release. The present study tested whether an opiate agonist and antagonist would affect the depletion of hypothalamic catecholamines observed after synthesis inhibition, as a measure of catecholamine activity, concomitant with changes in LH secretion. Administration of naloxone to estradiol-primed rats increased LH release and potentiated the depletion of norepinephrine in the preoptic-anterior hypothalamus and medial basal hypothalamus, and enhanced the decline of epinephrine and of dopamine in the medial basal hypothalamus, suggesting increased catecholamine activity in these regions. Administration of the opiate agonist, morphine, to estrogen/progesterone pretreated females decreased LH and decreased the depletion of the catecholamines in the above mentioned areas, suggesting reduced activity. In most cases, naloxone antagonized the inhibitory effect of morphine. These findings indicate that naloxone may stimulate LH release by enhancing hypothalamic catecholamine turnover, possibly by removing the inhibitory influence of an endogenous opioid neuropeptide.