D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity.
D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity.
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DOI：
10.1007/s00253-021-11676-2
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发表时间：
2021-12
影响因子：
5
通讯作者：
Chakraborty C
中科院分区：
文献类型：
--
作者：
Bhattacharya M;Chatterjee S;Sharma AR;Agoramoorthy G;Chakraborty C
COVID-19大流行的进展在全球范围内产生了许多新出现的SARS-CoV-2变体。这些变异已经获得了进化优势，包括高毒力和严重的传染性，由于多个刺突糖蛋白突变。因此，变异表现出逃避宿主免疫反应的显著能力。SARS-CoV-2变异体s糖蛋白的D614G突变显示出与细胞ACE2受体最有效的相互作用。这种氨基酸位置614的显性突变（天冬氨酸取代甘氨酸）是感染和再感染的主要原因。它改变了s糖蛋白的RBD构象和裂解模式，具有更高的稳定性、复制适合度和融合效率。因此，本综述旨在提供与SARS-CoV-2变体的D614突变发生及其感染模式相关的几个关键信息。本综述还将有效地强调该病毒的D614G突变体的作用机制、免疫逃逸和部分疫苗逃逸。此外，还强调了导致当前全球大流行状况的病毒特征变化。在这里，我们试图为未来的研究人员阐明一个新的方向，即开发有效的治疗方法和平衡策略，以最大限度地减少COVID-19的传播。•D614G突变出现在SARS-CoV-2显著变体的s糖蛋白内。•D614G突变影响SARS-CoV-2变体的感染、再感染、s -糖蛋白的切割模式和复制适应性。•D614G突变影响免疫和部分疫苗逃逸。
The progression of the COVID-19 pandemic has generated numerous emerging variants of SARS-CoV-2 on a global scale. These variants have gained evolutionary advantages, comprising high virulence and serious infectivity due to multiple spike glycoprotein mutations. As a reason, variants are demonstrating significant abilities to escape the immune responses of the host. The D614G mutation in the S-glycoprotein of SARS-CoV-2 variants has shown the most efficient interaction with the ACE2 receptor of the cells. This explicit mutation at amino acid position 614 (aspartic acid-to-glycine substitution) is the prime cause of infection and re-infection. It changes the conformation of RBD and cleavage patterns S-glycoprotein with higher stability, replication fitness, and fusion efficiencies. Therefore, this review aims to provide several crucial pieces of information associated with the D614 mutational occurrence of SARS-CoV-2 variants and their infectivity patterns. This review will also effectively emphasize the mechanism of action of D614G mutant variants, immune escape, and partial vaccine escape of this virus. Furthermore, the viral characteristic changes leading to the current global pandemic condition have been highlighted. Here, we have tried to illustrate a novel direction for future researchers to develop effective therapeutic approaches and counterweight strategies to minimize the spread of COVID-19. Key points • D614G mutation arises within the S-glycoprotein of significant SARS-CoV-2 variants. • The D614G mutation affects infection, re-infection, cleavage patterns of S-glycoprotein, and replication fitness of SARS-CoV-2 variants. • The D614G mutation influences the immunity and partial vaccine escape.
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
DOI：
10.1016/j.bbrc.2020.11.026
发表时间：
2021-01-29
影响因子：
3.1
作者：
Jackson CB;Zhang L;Farzan M;Choe H
通讯作者：
Choe H
DOI：
10.1016/j.meegid.2021.104815
发表时间：
2021-07
期刊：
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
影响因子：
--
作者：
Kwarteng A;Asiedu E;Sylverken AA;Larbi A;Sakyi SA;Asiedu SO
通讯作者：
Asiedu SO
影响因子：
6.4
作者：
Cheng YW;Chao TL;Li CL;Wang SH;Kao HC;Tsai YM;Wang HY;Hsieh CL;Lin YY;Chen PJ;Chang SY;Yeh SH
通讯作者：
Yeh SH
影响因子：
56.9
作者：
Cai, Yongfei;Zhang, Jun;Chen, Bing
通讯作者：
Chen, Bing