DNannotator: Annotation software tool kit for regional genomic sequences.
DNannotator: Annotation software tool kit for regional genomic sequences.
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DNannotator：区域基因组序列注释软件工具包。
DOI：
10.1093/nar/gkg542
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发表时间：
2003
影响因子：
14.9
通讯作者：
Gershon,ElliotS
中科院分区：
文献类型：
--
作者：
Liu,Chunyu;Bonner,TomI;Nguyen,Tu;Lyons,JenniferL;Christian,SusanL;Gershon,ElliotS
序列注释对于基于基因组学的研究至关重要。特定基因组区域的研究人员已经开发了丰富的本地发现（例如基因和遗传标记），或者从多个资源收集了注释，可能会因创建本地注释的困难以及集成所有注释的复杂性而不知所措。以适合数据挖掘和高通量实验设计的形式呈现此类综合数据更是令人望而生畏。 DNannotator 是一个 Web 应用程序，旨在对相当大的基因组区域执行批量注释。它采用由最终用户和/或基因组 DNA 的指定目标准备的注释源数据，例如 SNP、基因、引物等，并执行从头注释。 DNannotator 还可以稳健地将 GenBank 格式的现有注释从一个序列迁移到另一个序列。注释结果以 GenBank 格式和制表符分隔的文本形式提供，可以在数据库或电子表格中导入和管理，并根据需要与现有注释组合。图形查看器（例如 Genome Browser 或 Artemis）可以显示注释结果。可选择提供有助于用户评估注释质量的参考数据（过程报告）。 DNannotator 可以通过 http://sky.bsd.uchicago.edu/DNannotator.htm 访问。
Sequence annotation is essential for genomics-based research. Investigators of a specific genomic region who have developed abundant local discoveries such as genes and genetic markers, or have collected annotations from multiple resources, can be overwhelmed by the difficulty in creating local annotation and the complexity of integrating all the annotations. Presenting such integrated data in a form suitable for data mining and high-throughput experimental design is even more daunting. DNannotator, a web application, was designed to perform batch annotation on a sizeable genomic region. It takes annotation source data, such as SNPs, genes, primers, and so on, prepared by the end-user and/or a specified target of genomic DNA, and performsde novoannotation. DNannotator can also robustly migrate existing annotations in GenBank format from one sequence to another. Annotation results are provided in GenBank format and in tab-delimited text, which can be imported and managed in a database or spreadsheet and combined with existing annotation as desired. Graphic viewers, such as Genome Browser or Artemis, can display the annotation results. Reference data (reports on the process) facilitating the user's evaluation of annotation quality are optionally provided. DNannotator can be accessed at http://sky.bsd.uchicago.edu/DNannotator.htm.