Pancreatic Cysts in Autosomal Dominant Polycystic Kidney Disease: Prevalence and Association with PKD2 Gene Mutations
Pancreatic Cysts in Autosomal Dominant Polycystic Kidney Disease: Prevalence and Association with PKD2 Gene Mutations
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DOI：
10.1148/radiol.2016151650
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发表时间：
2016-09-01
期刊：
影响因子：
19.7
通讯作者：
Prince, Martin R.
中科院分区：
文献类型：
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作者：
Kim, Jin Ah;Blumenfeld, Jon D.;Prince, Martin R.
目的：定义胰腺囊肿的磁共振（MR）成像的患病率与常染色体显性遗传性多囊肾病（ADPKD）的患者队列与对照组相比，没有ADPKD的年龄，性别和肾功能相匹配的Materials and Methods：在这符合健康保险责任法案，机构审查委员会批准的研究，所有患者与ADPKD提供知情同意书;对照组，知情同意书被免除。在PKD 1或PKD 2中发现突变的ADPKD患者（n = 110）和无ADPKD或已知胰腺疾病的对照受试者（n = 110），这些受试者在年龄、性别、估计肾小球滤过率和MR成像检查日期方面相匹配，通过在1.5 T下获得的轴向和冠状面单次激发快速自旋回波T2加权图像评价胰腺囊肿。测量总肾脏体积和肝脏体积。进行单变量和多变量logistic回归分析，以评估收集的变量与ADPKD患者胰腺囊肿之间的潜在相关性。结果：ADPKD患者至少有一个胰腺囊肿的可能性明显高于对照组（40/110 [36%] vs 25/110 [23%]; P = 0.027）。在单变量分析中，胰腺囊肿在PKD 2突变的ADPKD患者中比PKD 1突变的ADPKD患者中更常见（34例患者中的21例[62%] vs 76例患者中的19例[25%]; P =.0002）。在多变量logistic回归模型中，PKD 2突变位点与胰腺囊肿（P = 0.0004）和肝脏体积（P = 0.038）显著相关。ADPKD和胰腺囊肿的患者是5.9倍，更有可能有PKD 2突变比PKD 1突变后调整年龄，种族，性别，估计肾小球滤过率，肝脏体积，和总的肾脏volume.Conclusion：胰腺囊肿是更普遍的ADPKD患者PKD 2突变比对照组或PKD 1突变的患者。(C)RSNA，2016
Purpose: To define the magnetic resonance (MR) imaging prevalence of pancreatic cysts in a cohort of patients with autosomal dominant polycystic kidney disease (ADPKD) compared with a control group without ADPKD that was matched for age, sex, and renal function.Materials and Methods: In this HIPAA-compliant, institutional review board-approved study, all patients with ADPKD provided informed consent; for control subjects, informed consent was waived. Patients with ADPKD (n = 110) with mutations identified in PKD1 or PKD2 and control subjects without ADPKD or known pancreatic disease (n = 110) who were matched for age, sex, estimated glomerular filtration rate, and date of MR imaging examination were evaluated for pancreatic cysts by using axial and coronal single-shot fast spin-echo T2-weighted images obtained at 1.5 T. Total kidney volume and liver volume were measured. Univariate and multivariable logistic regression analyses were conducted to evaluate potential associations between collected variables and presence of pancreatic cysts among patients with ADPKD. The number, size, location, and imaging characteristics of the cysts were recorded.Results: Patients with ADPKD were significantly more likely than control subjects to have at least one pancreatic cyst (40 of 110 patients [36%] vs 25 of 110 control subjects [23%]; P =.027). In a univariate analysis, pancreatic cysts were more prevalent in patients with ADPKD with mutations in PKD2 than in PKD1 (21 of 34 patients [62%] vs 19 of 76 patients [25%]; P =.0002). In a multivariable logistic regression model, PKD2 mutation locus was significantly associated with the presence of pancreatic cysts (P =.0004) and with liver volume (P =.038). Patients with ADPKD and a pancreatic cyst were 5.9 times more likely to have a PKD2 mutation than a PKD1 mutation after adjusting for age, race, sex, estimated glomerular filtration rate, liver volume, and total kidney volume.Conclusion: Pancreatic cysts were more prevalent in patients with ADPKD with PKD2 mutation than in control subjects or patients with PKD1 mutation. (C) RSNA, 2016