Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression
Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression
复制标题
紫堇碱通过调节 COX-2 表达抑制肠道病毒 71 复制
DOI：
10.1080/10286020.2017.1386658
复制
发表时间：
2017-01-01
影响因子：
1.7
通讯作者：
Li, Yu-Huan
中科院分区：
文献类型：
--
作者：
Wang, Hui-Qiang;Hu, Jin;Li, Yu-Huan
Abstract Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Based on these findings, corydaline could be a potential lead or supplement for the development of new anti-EV71 agents in the future.
