Deciphering the role of Th17 cells in human disease.
Deciphering the role of Th17 cells in human disease.
复制标题
DOI：
10.1016/j.it.2011.08.003
复制
发表时间：
2011-12
影响因子：
16.8
通讯作者：
Zou W
中科院分区：
文献类型：
--
作者：
Wilke CM;Bishop K;Fox D;Zou W
自2005年被发现以来，辅助性T (Th)17细胞已被认为在多种人类疾病中发挥重要作用，包括各种自身免疫性疾病、过敏、肿瘤的发生和进展以及移植器官和骨髓的接受或排斥。以人类研究为重点，我们回顾了这些领域中关于Th17生物学和功能的最新进展。Th17细胞积极参与自身免疫性疾病、过敏和移植排斥的发病过程。Th17细胞参与人类上皮恶性肿瘤的保护性抗肿瘤免疫，而Th17相关细胞因子也可能在慢性炎症和感染的背景下与肿瘤的发生和生长有关。还讨论了Th17细胞的体内可塑性如何可能是Th17细胞生物学在人类疾病中的一个重要特征。
Since their identification in 2005, T helper (Th)17 cells have been proposed to play important roles in several human diseases, including various autoimmune conditions, allergy, the development and progression of tumors, and the acceptance or rejection of transplanted organs and bone marrow. Focusing on human studies, here we review recent developments regarding Th17 biology and function in each of these fields. Th17 cells actively participate in the pathogenesis of autoimmune disease, allergy and transplantation rejection. Th17 cells contribute to protective anti-tumor immunity in human epithelial malignancy, while Th17-associated cytokines may also be associated with tumor initiation and growth in the context of chronic inflammation and infection. Also discussed is how the in vivo plasticity of Th17 cells may be an important feature of Th17 cell biology in human disease.
登录
查看更多内容
影响因子：
4.3
作者：
Barczyk, A;Pierzchala, W;Sozañska, E
通讯作者：
Sozañska, E
DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
人白细胞介素17产生的细胞起源于CD161+ CD4+ T细胞前体。
影响因子：
15.3
作者：
Cosmi, Lorenzo;De Palma, Raffaele;Santarlasci, Veronica;Maggi, Laura;Capone, Manuela;Frosali, Francesca;Rodolico, Gabriella;Querci, Valentina;Abbate, Gianfranco;Angeli, Roberta;Berrino, Liberato;Fambrini, Massimiliano;Caproni, Marzia;Tonelli, Francesco;Lazzeri, Elena;Parronchi, Paola;Liotta, Francesco;Maggi, Enrico;Romagnani, Sergio;Annunziato, Francesco
通讯作者：
Annunziato, Francesco
影响因子：
14.2
作者：
Cosmi, Lorenzo;Maggi, Laura;Annunziato, Francesco
通讯作者：
Annunziato, Francesco
影响因子：
--
作者：
Cosmi, Lorenzo;Cimaz, Rolando;Annunziato, Francesco
通讯作者：
Annunziato, Francesco