Impact of multiple substance use on circulating ST2, a biomarker of adverse cardiac remodelling, in women.
Impact of multiple substance use on circulating ST2, a biomarker of adverse cardiac remodelling, in women.
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DOI：
10.1080/1354750x.2022.2129451
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发表时间：
2022-12
期刊：
影响因子：
2.6
通讯作者：
Wu, Alan H. B.
中科院分区：
文献类型：
--
作者：
Riley, Elise D.;Kazi, Dhruv S.;Coffin, Phillip O.;Vittinghoff, Eric;Wade, Amanda N.;Bulfone, Tommaso C.;Lynch, Kara L.;Atai, Zahra;Wu, Alan H. B.
心血管疾病（CVD）和心力衰竭（HF）是低收入人群死亡的主要原因，性别不同。纳入心脏生物标志物的风险评估很常见。然而，评估生物标志物效用的研究很少包括受控物质，这可能会影响生物标志物水平，从而影响心血管疾病的风险评估。我们在245名低收入女性中发现了多种物质对可溶性“抑制致瘤性2”（sST2）的影响，sST2是一种不良心脏重构的生物标志物。调整心血管疾病风险因素后，我们在六个月的随访中检查了药物使用与sST2之间的关系。中位年龄为53岁，74%的参与者是少数民族女性。在≥1次研究访问期间，44%的参与者观察到sST2水平>35 ng/mL（表明心脏重构）。在校正分析中，较高的sST2水平与可卡因（校正线性效应[ALE]:1.10; 95% CI:1.03-1.19）、酒精（ALE:1.10; 95% CI:1.04-1.17）、海洛因（ALE:1.25; 95% CI:1.10-1.43）的存在以及海洛因和芬太尼使用之间的相互作用显著正相关。结果表明，使用多种物质会影响sST2水平，sST2是一种常用于评估心血管风险的生物标志物。将药物使用与心脏生物标志物结合可能改善易感妇女的心血管疾病风险评估。
Cardiovascular disease (CVD) and heart failure (HF) are major causes of mortality in low-income populations and differ by sex. Risk assessment that incorporates cardiac biomarkers is common. However, research evaluating the utility of biomarkers rarely includes controlled substances, which may influence biomarker levels and thus influence CVD risk assessment. We identified the effects of multiple substances on soluble “suppression of tumorigenicity 2” (sST2), a biomarker of adverse cardiac remodeling, in 245 low-income women. Adjusting for CVD risk factors, we examined associations between substance use and sST2 over six monthly visits. Median age was 53 years and 74% of participants were ethnic minority women. An sST2 level>35 ng/mL (suggesting cardiac remodeling) during ≥1 study visit was observed in 44% of participants. In adjusted analysis, higher sST2 levels were significantly and positively associated with the presence of cocaine (Adjusted Linear Effect [ALE]:1.10; 95% CI:1.03-1.19), alcohol (ALE:1.10; 95% CI:1.04-1.17), heroin (ALE:1.25; 95% CI:1.10-1.43), and the interaction between heroin and fentanyl use. Results suggest that the use of multiple substances influences the level of sST2, a biomarker often used to evaluate cardiovascular risk. Incorporating substance use alongside cardiac biomarkers may improve CVD risk assessment in vulnerable women.