Inosine improves functional recovery after experimental traumatic brain injury
Inosine improves functional recovery after experimental traumatic brain injury
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DOI：
10.1016/j.brainres.2014.01.044
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发表时间：
2014-03-25
期刊：
影响因子：
2.9
通讯作者：
Shohami, Esther
中科院分区：
文献类型：
--
作者：
Dachir, Shlomit;Shabashov, Dalia;Shohami, Esther
尽管经过多年的研究，目前还没有有效的治疗方法可用于治疗创伤性脑损伤（TBI）。TBI幸存者中最普遍和最衰弱的特征是认知缺陷和运动功能障碍。一种用于改善TBI后患者功能的潜在治疗方法将是以允许形成代偿回路的受控方式至少部分地恢复CNS的可塑性。肌苷是一种天然存在的嘌呤核苷，已被证明可促进中风和局灶性TBI后皮质脊髓束（CST）中的轴突侧支生长。在本研究中，我们研究了肌苷对闭合性脑损伤（CHI）实验模型中运动和认知缺陷、CST发芽和突触蛋白表达的影响。肌苷治疗（100 mg/kg，在CHI后1、24和48 h腹腔注射）改善了TBI后的结果，显著降低了神经系统严重程度评分（NSS，p
Despite years of research, no effective therapy is yet available for the treatment of traumatic brain injury (TBI). The most prevalent and debilitating features in survivors of TBI are cognitive deficits and motor dysfunction. A potential therapeutic method for improving the function of patients following TBI would be to restore, at least in part, plasticity to the CNS in a controlled way that would allow for the formation of compensatory circuits. Inosine, a naturally occurring purine nucleoside, has been shown to promote axon collateral growth in the corticospinal tract (CST) following stroke and focal TBI. In the present study, we investigated the effects of inosine on motor and cognitive deficits, CST sprouting, and expression of synaptic proteins in an experimental model of closed head injury (CHI). Treatment with inosine (100 mg/kg i.p. at 1, 24 and 48 h following CHI) improved outcome after TBI, significantly decreasing the neurological severity score (NSS, p