Global organization of functional brain connectivity in methamphetamine abusers
Global organization of functional brain connectivity in methamphetamine abusers
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DOI：
10.1016/j.clinph.2012.12.003
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发表时间：
2013-06-01
影响因子：
4.7
通讯作者：
Azad-Marzabadi, Esfandiar
中科院分区：
文献类型：
--
作者：
Ahmadlou, Mehran;Ahmadi, Khodabakhsh;Azad-Marzabadi, Esfandiar
目的：本研究旨在确定慢性甲基苯丙胺（MA）滥用对功能性大脑连接的整体组织的影响。
方法：使用32通道系统记录36名甲基苯丙胺滥用者和36名年龄匹配的健康受试者闭眼静息态脑电图。去除伪迹后的脑电图（1 - 60Hz）被分解为常规脑电图频段。利用可见性图相似性（VGS）和相干性方法，构建每个脑电图频段的VGS和相干性矩阵。然后计算所有脑电图频段中VGS和相干性矩阵的小世界网络特性，即聚类系数（C）、平均路径长度（L）和C/L。接着使用曼 - 惠特尼检验和人工神经网络评估两组之间C、L和C/L的差异。
结果：甲基苯丙胺滥用者在伽马频段表现出更高的C、更低的L和更高的C/L（p值<0.05）。在其他频段，两组之间的这些指标没有显著差异（p值>0.05）。人工神经网络分析表明，伽马频段的C、L和C/L能够以83.3%的准确率区分甲基苯丙胺滥用者和健康受试者。
结论：慢性甲基苯丙胺滥用可能改变大脑在伽马频段的功能性连接，使其具有小世界网络特性的改变。这些发现可能为理解甲基苯丙胺滥用相关的大脑功能障碍提供新的视角。
Objective: This study aimed to determine effects of chronic methamphetamine (MA) abuse on global organization of the functional brain connectivity.Methods: Eyes-closed resting-state EEGs of 36 MA abusers and 36 age-matched healthy subjects were recorded using a 32-channel system. The EEGs (1-60 Hz), after removing artifacts, were decomposed into the conventional EEG bands. Using visibility graph similarity (VGS) and coherence methods, the VGS and coherence matrices in each EEG band were constructed. Then the Small-World Network properties, clustering coefficient (C), mean path length (L) and C/L, of the VGS and coherence matrices, were computed in all EEG bands. Then using the Mann-Whitney test and an artificial neural network the differences of C, L and C/L between the two groups were evaluated.Results: The MA abusers showed higher C, lower L and higher C/L at the gamma band (p-value