NF-κB inducing kinase: a key regulator in the immune system and in cancer.
NF-κB inducing kinase: a key regulator in the immune system and in cancer.
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DOI：
10.1016/j.cytogfr.2010.06.002
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发表时间：
2010-08
影响因子：
13
通讯作者：
Richmond, Ann
中科院分区：
文献类型：
--
作者：
Thu, Yee Mon;Richmond, Ann
NF-κB 诱导激酶 (NIK) 是一种激活经典和非经典 NF-κB 通路以控制某些蛋白质（如细胞因子、趋化因子和 NF-κB 信号分子）转录表达的激酶。在理解调节 NIK 稳定性以影响下游信号传导的分子机制方面已经取得了许多进展。遗传小鼠模型表明 NIK 在免疫系统和骨微环境的调节中具有重要作用。越来越多的证据将 NIK 与血液癌症（如多发性骨髓瘤）和实体瘤（如胰腺癌和黑色素瘤）的肿瘤发生联系起来。了解 NIK 解除管制的机制可能会为某些疾病（例如自身免疫和癌症）提供治疗选择。
NF-κB inducing kinase (NIK) is a kinase that activates the canonical and non-canonical NF-κB pathways to control transcriptional expression of certain proteins such as cytokines, chemokines and NF-κB signaling molecules. Many advances have been made in understanding the molecular mechanisms by which the stability of NIK is regulated to affect downstream signaling. Genetic mouse models suggest that NIK has an essential role in regulation of the immune system as well as in the bone microenvironment. Increasing evidence links NIK to the tumorigenesis of hematological cancers, such as multiple myeloma, and solid tumors, such as pancreatic carcinoma and melanoma. Understanding the mechanism by which NIK is de-regulated will potentially provide therapeutic options for certain diseases such as autoimmunity and cancer.
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影响因子：
32.4
作者：
Dejardin, E;Droin, NM;Green, DR
通讯作者：
Green, DR
DOI：
10.1073/pnas.0603493103
发表时间：
2006-09-26
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
8
作者：
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通讯作者：
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影响因子：
56.9
作者：
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通讯作者：
Karin, M