Association of Body Mass Index With Incidence and Progression of Knee Effusion on Magnetic Resonance Imaging and on Knee Examination
Association of Body Mass Index With Incidence and Progression of Knee Effusion on Magnetic Resonance Imaging and on Knee Examination
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DOI：
10.1002/acr.22714
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发表时间：
2016-04-01
影响因子：
4.7
通讯作者：
Cibere, Jolanda
中科院分区：
文献类型：
--
作者：
Hung, Amy;Sayre, Eric C.;Cibere, Jolanda
客观的。在膝关节疼痛的纵向队列中，通过磁共振成像 (MRI) 和体格检查 (PE) 确定体重指数 (BMI) 与膝关节积液的发生率和进展之间的关系。方法。在基线和 3 年期间对基于人群的队列进行了评估 (n = 163)。 BMI 被归类为正常 (= 30)。 MRI 上膝关节积液分级为 0-3（不存在/轻度/中度/重度），PE 分级为 0-1（不存在/存在）。基线时 1 级或 2 级患者的 MRI 积液进展 (MRIeff) 增加≥1 级。事件 MRIeff 和 PE 积液 (PEeff) 是基线 0 级患者随访时 (>0) 的任何积液。第二种类型的事件 MRIeff 是随访时积液等级 = 1 的患者，事件 MRIeff >= 2、事件 PEeff 和 MRIeff 进展分别见于 73 例中的 14 例 (19%)、140 例中的 18 例 (13%)、127 例中的 26 例 (20%) 和 86 例中的 18 例 (21%)。肥胖与 MRIeff 进展（风险比 [HR] 3.3 [95% 置信区间 (95% CI) 1.0-11.2]）以及事件 MRIeff >= 2（HR 3.4 [95% CI 1.0-11.5]）之间存在边缘统计相关性。 BMI 与 MRIeff >= 1 的事件无关（HR 超重 1.1 [95% CI 0.3-3.6]，肥胖 1.0 [95% CI 0.2-5.0]）。超重与 PEeff 事件相关（HR 4.5 [95% CI 1.4-14.2]），而肥胖则无统计学意义（HR 3.1 [95% CI 0.9-11.1]）。结论。在这个基于人群的队列中，肥胖是发生和进行性膝关节积液的危险因素。这些发现强调了肥胖与膝骨关节炎炎症之间的重要联系。
Objective. To determine the association of body mass index (BMI) with incidence and progression of knee effusion on magnetic resonance imaging (MRI) and physical examination (PE) in a longitudinal cohort with knee pain.Methods. A population-based cohort was assessed at baseline and 3 years (n = 163). BMI was categorized as normal (= 30). Knee effusion was graded as 0-3 (absent/mild/moderate/severe) on MRI and 0-1 (absent/present) on PE. Progression of MRI effusion (MRIeff) was an increase of >= 1 grade in those with grade 1 or 2 at baseline. Incident MRIeff and PE effusion (PEeff) were any effusion at followup (>0) in those with grade 0 at baseline. A second type of incident MRIeff was effusion grade >= 2 at followup in those with grade = 1, incident MRIeff >= 2, incident PEeff, and progression of MRIeff were seen in 14 of 73 (19%), 18 of 140 (13%), 26 of 127 (20%), and 18 of 86 (21%), respectively. There was a borderline statistical association of obesity with progression of MRIeff (hazard ratio [HR] 3.3 [95% confidence interval (95% CI) 1.0-11.2]) and with incident MRIeff >= 2 (HR 3.4 [95% CI 1.0-11.5]). BMI was not associated with incident MRIeff >= 1 (HR overweight 1.1 [95% CI 0.3-3.6], obese 1.0 [95% CI 0.2-5.0]). Overweight was associated with incident PEeff (HR 4.5 [95% CI 1.4-14.2]), while obesity was not statistically significant (HR 3.1 [95% CI 0.9-11.1]).Conclusion. Obesity was a risk factor for incident and progressive knee effusion in this population-based cohort. These findings highlight an important link between obesity and inflammation in knee osteoarthritis.