Fully substituted unsaturated lactones from endophytic Myrothecium sp.
Fully substituted unsaturated lactones from endophytic Myrothecium sp.
复制标题
来自内生菌斑菌属 (Myrothecium sp.) 的完全取代的不饱和内酯。
DOI：
10.1080/10286020.2011.605356
复制
发表时间：
2011-01-01
影响因子：
1.7
通讯作者：
Tan, Ren-Xiang
中科院分区：
文献类型：
--
作者：
Xu, Hao;Jiang, Nan;Tan, Ren-Xiang
从青梅（Vatica mangachapoi Blauco）根部分离的漆斑菌（Myrothecium sp.）IFB-E 106的发酵液中分离得到两个新的α，β-不饱和γ-内酯，即漆斑内酯A（1）和B（2）。绝对构型由计算电子圆二色性方法确定。肌内酯B显示出神经氨酸酶抑制活性，IC 50值为13.95 μ M。
Two new alpha,beta-unsaturated gamma-lactones, myrolactones A (1) and B (2), were characterized from the culture broth of the Myrothecium sp. IFB-E106 isolated from the roots of Vatica mangachapoi Blauco. The absolute configuration was determined by the computational electronic circular dichroism approach. Myolactone B showed neuraminidase inhibitory activity with the IC50 value of 13.95 mu M.