Evaluation of systemic activity of pediatric primary Sjogren's syndrome by EULAR Sjogren's syndrome disease activity index (ESSDAI)
Evaluation of systemic activity of pediatric primary Sjogren's syndrome by EULAR Sjogren's syndrome disease activity index (ESSDAI)
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DOI：
10.1080/14397595.2018.1452174
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发表时间：
2019-01-02
影响因子：
2.2
通讯作者：
Ariga, Tadashi
中科院分区：
文献类型：
--
作者：
Kobayashi, Ichiro;Okura, Yuka;Ariga, Tadashi
目的：本研究的目的是使用欧洲抗风湿联盟（EULAR）的干燥综合征疾病活动指数（ESSDAI）评估儿童干燥综合征（SS）的全身疾病活动性。研究方法：我们回顾性分析了KKR札幌医疗中心、北海道大学医院和附属医院根据1999年日本SS诊断标准诊断的16岁以前SS患者的病历。我们分析了临床和实验室数据，并计算了诊断和峰值活动时的ESSDAI。结果：入组了25名患者（2名男孩和23名女孩）。只有4例患者在诊断时有干燥症状。诊断时和活动峰值时的平均ESSDAI评分分别为12.68（2-31）和15.08（2-38）。仅3例患者无活动（ESSDAI评分
Objectives: The purpose of this study is to evaluate systemic disease activity of pediatric Sjogren's syndrome (SS) using European League Against Rheumatism (EULAR) Sjogren's syndrome disease activity index (ESSDAI). Methods: We retrospectively reviewed medical records of patients with SS who have been diagnosed according to 1999 Japanese diagnostic criteria for SS before 16 years old at KKR Sapporo Medical Center, Hokkaido University Hospital, and affiliated hospitals. We analyzed clinical and laboratory data and calculated ESSDAI at both diagnosis and peak activity. Results: Twenty-five patients (2 boys and 23 girls) were enrolled. Only 4 patients had sicca symptoms at diagnosis. Mean ESSDAI scores at diagnosis and peak activity were 12.68 (2-31) and 15.08 (2-38), respectively. Only 3 patients were inactive (ESSDAI score