Plasma growth hormone during sleep in young and aged men.
Plasma growth hormone during sleep in young and aged men.
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年轻和老年男性睡眠期间的血浆生长激素。
DOI：
10.1093/geronj/38.5.519
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Karacan,I
中科院分区：
文献类型：
--
作者：
Prinz,PN;Weitzman,ED;Cunningham,GR;Karacan,I
通过留置静脉插管，以20分钟的间隔测量血浆生长激素，显示16名健康老年男性与14名健康年轻男性相比，血浆生长激素显著降低。生长激素的降低完全局限于夜间的前3小时（积分水平的M± SEM分别为5.0 ± 1.2和21 ± 4.2 ng. hr/ml）。后半夜的生长激素水平没有差异。在5名老年人和9名年轻人中，每小时测量一次白天和晚上的生长激素水平，没有发现年龄效应。已知生长激素释放与睡眠开始相关，特别是与慢波睡眠阶段3和4相关，这些老年男性的睡眠量减少（老年组和年轻组的睡眠时间分别为9.9 ± 1.9和22.8 ± 2.3%）。睡眠阶段3和4与年轻和老年男性的生长激素水平显著相关（R= 0.463，p <0.01），但单独对任何一个年龄组都不相关，表明生长激素与慢波睡眠没有直接、简单的关系。
Plasma growth hormone measured at 20-min intervals across the night via indwelling venous cannula revealed a significant reduction in 16 healthy aged men as compared with 14 healthy young men. The decrease in growth hormone was entirely confined to the first 3 hours of the night (M±SEMfor the integrated level was 5.0 ± 1.2 and 21 ± 4.2 ng.hr/ml). Growth hormone levels across the latter part of the night did not differ. Day and evening growth hormone levels measured hourly in five of the aged and nine of the young men failed to reveal an age effect. Growth hormone release is known to be associated with sleep onset, and particularly with slow wave sleep, stage 3 and 4, which was reduced in amount in these aged men (9.9 ± 1.9 and 22.8 ± 2.3% of time in bed for aged and young groups, respectively). Sleep stage 3 and 4 correlated significantly with growth hormone level (R= .463,p< .01) for young and aged men combined, but not for either age group alone, indicating that growth hormone does not have a direct, simple relationship with slow wave sleep.