Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer.
Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer.
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富含G的寡核苷酸AS1411作为癌症的新治疗方法的发现和开发。
DOI：
10.1016/j.yexmp.2009.01.004
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发表时间：
2009-06
影响因子：
3.6
通讯作者：
Trent, John O.
中科院分区：
文献类型：
--
作者：
Bates, Paula J.;Laber, Damian A.;Miller, Donald M.;Thomas, Shelia D.;Trent, John O.
Certain guanine-rich (G-rich) DNA and RNA molecules can associate intermolecularly or intramolecularly to form four stranded or “quadruplex” structures, which have unusual biophysical and biological properties. Several synthetic G-rich quadruplex-forming oligodeoxynucleotides have recently been investigated as therapeutic agents for various human diseases. We refer to these biologically active G-rich oligonucleotides as aptamers because their activities arise from binding to protein targets via shape-specific recognition (analogous to antibody-antigen binding). As therapeutic agents, the G-rich aptamers may have some advantages over monoclonal antibodies and other oligonucleotide-based approaches. For example, quadruplex oligonucleotides are non-immunogenic, heat stable and they have increased resistance to serum nucleases and enhanced cellular uptake compared to unstructured sequences. In this review, we describe the characteristics and activities of G-rich oligonucleotides. We also give a personal perspective on the discovery and development of AS1411, an antiproliferative G-rich phosphodiester oligonucleotide that is currently being tested as an anticancer agent in Phase II clinical trials. This molecule functions as an aptamer to nucleolin, a multifunctional protein that is highly expressed by cancer cells, both intracellularly and on the cell surface. Thus, the serendipitous discovery of the G-rich oligonucleotides also led to the identification of nucleolin as a new molecular target for cancer therapy.
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DOI：
10.1111/j.1742-4658.2006.05471.x
发表时间：
2006-10
期刊：
The FEBS journal
影响因子：
--
作者：
Alete DE;Weeks ME;Hovanession AG;Hawadle M;Stoker AW
通讯作者：
Stoker AW
一种新型的受体 - francisella tularensis在单核细胞样THP-1细胞中的配体途径：表面核素与细菌伸长因子TU之间的相互作用。
影响因子：
4.2
作者：
Barel, Monique;Hovanessian, Ara G.;Meibom, Karin;Briand, Jean-Paul;Dupuis, Marion;Charbit, Alain
通讯作者：
Charbit, Alain
影响因子：
7.4
作者：
Cao, ZH;Huang, CC;Tan, WH
通讯作者：
Tan, WH
影响因子：
5.4
作者：
Bose, S;Basu, M;Banerjee, AK
通讯作者：
Banerjee, AK
影响因子：
3.6
作者：
Biessen, EAL;Vietsch, H;van Berkel, TJC
通讯作者：
van Berkel, TJC