Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells

Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells
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DOI:
10.1016/s0167-5699(00)01590-5
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发表时间:
2000-04-01
期刊:
IMMUNOLOGY TODAY
影响因子:
--
通讯作者:
Sinigaglia, F
Sinigaglia, F
中科院分区:
其他
文献类型:
--
作者:
D'Ambrosio, D;Iellem, A;Sinigaglia, F

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The recruitment of T helper 1 (Th1) and Th2 cells into peripheral tissues is essential for inflammation and the host response to infections. Here, Daniele D'Ambrosio and colleagues review the traffic signals that enable the distinct positioning of Th1 and Th2 cells and argue that differential thresholds for extravasation constitute a critical aspect of their selective localization to inflamed tissues.