BIOENERGETIC THEORY OF PROSTATE MALIGNANCY
BIOENERGETIC THEORY OF PROSTATE MALIGNANCY
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DOI：
10.1002/pros.2990250308
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发表时间：
1994-09-01
期刊：
影响因子：
2.8
通讯作者：
FRANKLIN, RB
中科院分区：
文献类型：
--
作者：
COSTELLO, LC;FRANKLIN, RB
正常和良性前列腺增生（BPH）前列腺的特征是存在极高水平的柠檬酸盐。据推测，这是由于前列腺上皮细胞由于限制性线粒体（m-）顺乌头酸酶而不能氧化柠檬酸盐。相比之下，前列腺癌（CA）的特征不是高柠檬酸盐水平。恶性前列腺上皮细胞显然经历从柠檬酸盐产生细胞到柠檬酸盐氧化细胞的代谢转化。正常和BPH细胞中柠檬酸盐产生的结果是ATP产生的效率低和水平低。有人提出，恶性肿瘤的过程需要的能量生产，不能由柠檬酸生产细胞提供。因此，前列腺上皮细胞转化为柠檬酸氧化细胞，增加能量生产能力是恶性肿瘤和转移过程所必需的。代谢转化可能发生在癌前或早期恶性阶段。这种前列腺恶性肿瘤的生物能量学理论，如果正确的话，将为CA的诊断和治疗提供新的途径。(C)1994 Wiley-Liss，Inc.
Normal and benign prostate hyperplasia (BPH) prostate is characterized by the presence of extraordinarily high levels of citrate. Presumably, this results from the inability of the prostate epithelial cells to oxidize citrate due to a limiting mitochondrial (m-) aconitase. In contrast, prostate carcinoma (CA) is not characterized by high citrate levels. Malignant prostate epithelial cells apparently undergo a metabolic transformation from citrate-producing to citrate-oxidizing cells. A consequence of citrate production in normal and BPH cells is an inefficient and low level of ATP production. It is proposed that the process of malignancy necessitates an energy production that cannot be provided by citrate-producing cells. Consequently, the transformation of prostate epithelial cells to citrate-oxidizing cells which increases the energy production capability is essential to the process of malignancy and metastasis. The metabolic transformation likely occurs as a premalignant or early malignant stage. This bioenergetic theory of prostate malignancy, if correct, will provide new approaches to the diagnosis and treatment of CA. (C) 1994 Wiley-Liss, Inc.