RETINOHYPOTHALAMIC PROJECTIONS IN THE HAMSTER AND RAT DEMONSTRATED USING CHOLERA-TOXIN
RETINOHYPOTHALAMIC PROJECTIONS IN THE HAMSTER AND RAT DEMONSTRATED USING CHOLERA-TOXIN
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DOI：
10.1016/0006-8993(88)90558-6
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发表时间：
1988-10-18
期刊：
影响因子：
2.9
通讯作者：
MOORE, RY
中科院分区：
文献类型：
--
作者：
JOHNSON, RF;MORIN, LP;MOORE, RY
采用霍乱毒素偶联HRP （CT-HRP）的顺行转运方法研究了大鼠和仓鼠视网膜下丘脑束（RHT）投射的组织。在这两个物种中，主要的RHT投射导致视交叉上核（SCN）。这种投射开始于吻侧SCN，在仓鼠中是一个松散的神经丛，在大鼠中是沿交叉边界密集聚集的终端。在SCN的其余部分，在核的腹侧和外侧部分有一个非常密集的末梢丛，中间部分有较少的末梢丛。在大鼠中，对侧RHT到SCN的投射更大，而在仓鼠中，对侧和同侧投射大致相等。除了投射到SCN外，两种动物的RHT还投射到下丘脑前区、交叉后区和下丘脑外侧区。仓鼠的下丘脑前突比大鼠更广泛，并延伸到皮层周围区、下丘脑背区和中间带。SCN和下丘脑前部投射是连续的，一个投射到交叉后区，在仓鼠中，一个投射延伸到室上区，一些外显子和终端继续进入室旁核。与此相反，大鼠的外侧下丘脑投射比仓鼠更广泛。白化鼠和色素沉着鼠表现出相同的投影。除了下丘脑的投射外，仓鼠沿端脑底部有一个小的投射到杏仁核前区和皮质杏仁核，还有一个非常稀疏的投射到丘脑前核。因此，CT-HRP方法显示出比其他顺行转运方法更广泛的RHT投影。这在下丘脑前部和外侧投影中尤为明显。大鼠和仓鼠在RHT突起的组织上存在显著差异，仓鼠在丘脑和杏仁核上有较小的视网膜突起，这在大鼠中不存在。
The organization of retinohypothalamic tract (RHT) projections in the rat and hamster was studied using anterograde transport of cholera toxin conjugated to HRP (CT-HRP). In both species the major RHT projections lead to the suprachiasmatic nuclei (SCN). This projections begins in the rostral SCN as a loose plexus in the hamster and as a dense aggregation of terminals along the chiasmal border in the rat. Through the remainder of the SCN there is a very dense terminal plexus in the ventral and lateral part of the nucleus with fewer terminals present medially. The RHT projection to the SCN is greater contralaterally in the rat whereas in the hamster the contralateral and ipsilateral projections are approximately equal. In addition to projections to the SCN, the RHT projects to the anterior hypothalamic area, the retrochiasmatic area and lateral hypothalamic area in both species. The anterior hypothalamic projections are more extensive in the hamster than in the rat and extend into the perifornical region, the dorsal hypothalamus and zona incerta. The SCN and anterior hypothalamic projections are continuous with a projection to the retrochiasmatic area and, in the hamster, with a projection extending into the supraventricular zone with some exons and terminals continuing into the paraventricular nucleus. In contrast to these, the lateral hypothalamic projection in the rat is more extensive than in the hamster. Albino and pigmented rats show identical projections. In addition to the hypothalamic projections, there is in the hamster a small projection along the base of the telencephalon to the anterior amygdaloid area and cortical amygdaloid nucleus and a very sparse projection to the anterior thalamic nuclei. Thus, the CT-HRP method demonstrates a much more extensive RHT projection than has been demonstrated with other anterograde transport methods. This is particularly evident in the anterior and lateral hypothalamic projections. There are significant differences between rat and hamster in the organization of RHT projections and the hamster has small retinal projections to the thalamus and amygdala that are not present in the rat.