Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy
Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy
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DOI：
10.1002/adma.201601902
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发表时间：
2016-09-07
影响因子：
29.4
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Chen, Qian;Feng, Liangzhu;Liu, Zhuang
提出了一种基于白蛋白包覆MnO 2的独特的pH/H2 O2双响应智能纳米给药系统，该系统能够通过缓解缺氧来调节肿瘤微环境（TME）。此外，TME响应性尺寸变化能够实现有效的肿瘤内扩散。在小鼠肿瘤模型中，利用这些纳米颗粒实现了高效的光动力学和化学疗法的组合。
A unique type of pH/H2O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.