The gene for the atrial natriuretic factor is expressed in the aortic arch.
The gene for the atrial natriuretic factor is expressed in the aortic arch.
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心房钠尿因子基因在主动脉弓中表达。
DOI：
10.1161/01.hyp.9.1.103
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Baxter,JD
中科院分区：
文献类型：
--
作者：
Gardner,DG;Deschepper,CF;Baxter,JD
心房利钠因子基因在大鼠主动脉弓的外膜细胞内表达。在主动脉弓中发现了心房利钠因子转录本，其总体大小（1100-1200个核苷酸）和5 '末端与心房中发现的转录本相似。这些转录本的水平要低得多（约10-20%）存在于胸主动脉远端。免疫细胞化学显示，心房利钠因子肽位于主动脉弓外膜的压力感受器所在区域。这些数据表明，以前未被怀疑的作用，肽调节全身血压通过压力感受器反射。
The gene for atrial natriuretic factor is expressed within the adventitial cells of the rat aortic arch. Atrial natriuretic factor transcripts, similar in overall size (1100-1200 nucleotides) and 5'-termini to those found in the atria, were identified in the arch. Much lower levels (approximately 10-20%) of these transcripts were present in distal thoracic aorta. Atrial natriuretic factor peptide was localized by immunocytochemistry to the adventitia of the arch in regions thought to harbor the aortic baroreceptors. These data suggest a previously unsuspected role for the peptide in regulating systemic blood pressure through the baroreceptor reflex.