Risk factors for fracture in a UK population: a prospective cohort study
Risk factors for fracture in a UK population: a prospective cohort study
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DOI：
10.1093/qjmed/hch097
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发表时间：
2004-09-01
影响因子：
13.3
通讯作者：
Watt, I
中科院分区：
文献类型：
--
作者：
Porthouse, J;Birks, YF;Watt, I
背景：已确定老年女性骨折的常见临床危险因素。迄今为止，大多数这些危险因素尚未在英国人群中得到证实。目的：确认老年女性骨折的重要危险因素。设计：采用巢式随机对照试验的综合队列研究 (CCS)。方法：CCS 包括 4292 名年龄 > 70 岁的女性。我们评估了骨折的潜在危险因素，并对参与者进行了 24 个月的随访，了解非椎骨骨折的发生率。结果：预测任何非椎骨骨折的比值比 (OR) 为：既往骨折，2.67 (95%Cl 2.10-3.40)；过去 12 个月下降，2.06 (95% CI 1.63-2.59)；和年龄（每年增加）1.03 (95% CI 1.01-1.05)。预测髋部骨折的 OR 为：既往骨折史，2.31（95% CI 1.31-4.08）；低体重（
Background: Common clinical risk factors for fracture in older women have been identified. To date, most of these risk factors have not been confirmed in a UK population.Aim: To confirm the important risk factors for fracture in older women.Design: Comprehensive cohort study (CCS) with a nested randomized controlled trial.Methods: The CCS included 4292 women aged >70 years. We assessed potential risk factors for fracture, and followed-up participants for 24 months for incidence of non-vertebral fractures.Results: Odds ratios (ORs) for predicting any nonvertebral fracture were: previous fracture, 2.67 (95%Cl 2.10-3.40); a fall in the last 12 months, 2.06 (95% CI 1.63-2.59); and age (per year increase), 1.03 (95% CI 1.01-1.05). ORs for predicting hip fracture were: previous fracture, 2.31 (95% CI 1.31-4.08); low body weight (