Acarbose treatment of non-insulin-dependent diabetes mellitus.
Acarbose treatment of non-insulin-dependent diabetes mellitus.
复制标题
阿卡波糖治疗非胰岛素依赖型糖尿病。
作者：
C. Lardinois;M. Greenfield;H. Schwartz;H. Vreman;G. Reaven
阿卡波糖是一种新开发的肠道α-葡萄糖苷酶抑制剂，在目前的研究中，我们研究了12名非胰岛素依赖型糖尿病患者对其降低血糖水平的能力，这些患者的饮食和磺脲类药物控制不佳。在阿卡波糖加入治疗方案前和3个月后，对患者进行了研究，餐后血糖浓度显著下降，约为60 mg/dL。当5名患者停止阿卡波糖治疗时，血糖水平迅速恢复到治疗前水平。除了血糖的改善外，阿卡波糖治疗还导致Hb A1c和甘油三酯浓度显著降低。最后，对阿卡波糖的反应有相当大的个体差异，在四名患者中的结果相当显著，空腹和餐后血糖浓度都显著降低。这些数据表明，阿卡波糖可能是治疗非胰岛素依赖型糖尿病患者的有用补充。
Acarbose is a newly developed inhibitor of intestinal alpha-glucosidase, and in the current study its ability to lower plasma glucose levels was studied in 12 patients with non-insulin-dependent diabetes mellitus, poorly controlled on diet plus sulfonylurea drugs. Patients were studied before and three months after the addition of acarbose to their treatment program, and there was a notable fall in postprandial plasma glucose concentrations that approximated 60 mg/dL. When acarbose therapy was discontinued in five patients, plasma glucose levels rapidly returned toward pretreatment levels. In addition to the improvement in glycemia, acarbose treatment also led to a notable reduction in Hb A1c and triglyceride concentrations. Finally, considerable individual variation was noted in the response to acarbose, and the results in four patients were quite dramatic, with striking reductions in both fasting and postprandial glucose concentrations. These data suggest that acarbose may be a useful addition in the treatment of patients with non-insulin-dependent diabetes mellitus.
高血糖本身对非胰岛素依赖型糖尿病患者的葡萄糖处理和清除的影响。
DOI：
10.1210/jcem-56-4-819
发表时间：
1983
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Best,JD;Beard,JC;TaborskyJr,GJ;Halter,JB;PorteJr,D
通讯作者：
PorteJr,D