Morphology control of molecular assemblies prepared from bio-based amphiphilic polymers with a helical hydrophobic unit and application as nanocarriers for contrast agents and/or drug delivery
Morphology control of molecular assemblies prepared from bio-based amphiphilic polymers with a helical hydrophobic unit and application as nanocarriers for contrast agents and/or drug delivery
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DOI：
10.1038/pj.2014.73
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发表时间：
2014-11
期刊：
影响因子：
2.8
通讯作者：
Akira Makino
中科院分区：
文献类型：
--
作者：
Akira Makino
具有螺旋疏水单元的生物基两亲聚合物在分子组装及其形态方面得到了广泛的研究。为了利用螺旋单元的特定特征，例如在左右螺旋之间形成螺旋和立体络合物，必须制备比传统管和囊泡更复杂的形态。基于立体络合物形成的膜足够稳定，可以诱导相分离，从而导致独特的自组装，“拼凑自组装”。生成的分子组装是热力学稳定的，在某些情况下，表现出膜流动性，因为有规则排列的螺旋疏水单元有助于分子组装，并允许组装中的螺旋的平移扩散。该分子组装体的物理性质可进行精细调节，并可作为药物递送系统的载体。乳小体是一个直径为35纳米的聚合物胶束。在移植瘤模型小鼠的体内实验中，乳小体通过增强的渗透性和滞留性（EPR）作用选择性地积聚在肿瘤区域，并被生物体的自我防御系统捕获。因此，乳小体可能是DDS的极好载体。
Bio-based amphiphilic polymers with a helical hydrophobic unit have been studied extensively with regard to molecular assemblies and their morphology. To use specific characteristics of the helical units, such as coiled-coil and stereocomplex formation between the right-and left-handed helices, morphologies more complex than conventional tubes and vesicles must be prepared. Membranes based on stereocomplex formation were sufficiently stable to induce phase separation, which led to a unique self-assembly,‘patchwork self-assembly’. The molecular assemblies generated were thermodynamically stable and, in certain cases, exhibited membrane fluidity because the regularly aligned helical hydrophobic units contribute to the molecular assembly and allow for translational diffusion of the helices in the assemblies. The molecular assembly physical properties can be finely tuned, and the assemblies were used as carriers for drug delivery systems (DDSs). The lactosome is a polymeric micelle 35 nm in diameter. In in vivo experiments using transplanted tumor model mice, the lactosome selectively accumulated at tumor regions through an enhanced permeability and retention (EPR) effect, and its entrapment by self-defense systems of living organisms was significantly suppressed. Therefore, the lactosome is likely an excellent carrier for DDS.